Best Treatments for persistent Hostility and Aggression in Persons with Schizophrenia spectrum disorders

The incidence of aggressive behaviors is higher among persons with schizophrenia spectrum disorders (SSDs) than among persons without such disorders. This phenomenon represents a risk to the well-being of patients, their families, and society.


Clozapine is also possibly more effective than olanzapine or haloperidol for reducing aggression among selected physically assaultive inpatients (Level C). Adjunctive propranolol, valproic acid, and famotidine are possibly effective for reducing some aspects of hostility or aggression among inpatients with SSDs (Level C). Paliperidone-extended release currently appears to be the agent for the management of hostility among inpatients with SSDs for which there is the strongest evidence of efficacy.


I haven’t gotten a good response but I think once you identify your negatives then you can change them so I’m not sure how much meds help but I think sometimes you have to correct things thru classes or support and not so much medication.

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