Researchers have also found strong connections between the gut microbiome and schizophrenia and bipolar disorder.28 As recently reported by Psych Central
Gut Bacteria May Play a Role in Bipolar Disorder and Schizophrenia
Researchers have also found strong connections between the gut microbiome and schizophrenia and bipolar disorder.28 As recently reported by Psych Central:29
"The gut and the brain are connected by what is called the enteric nervous system [ENS]. While the ENS can act independently, it can also influence the central nervous system. It does this through millions of neurons as well as neurotransmitters like serotonin, dopamine, glutamate and norepinephrine. When one of these systems dysfunctions, it can heavily impact the other, causing symptoms of depression and anxiety.
One way the digestive system can dysfunction is with an alteration in the gut’s microbiome. The immune system is also vulnerable to changes in the microbiome … Part of the immune response to harmful microorganisms is inflammation. This inflammation occurs throughout the body, including areas around the brain, which can trigger or worsen symptoms of bipolar disorder."
For example, studies have found:
Schizophrenics have less biodiversity overall and 400 times higher population of lactic acid producing bacteria than healthy individuals. Certain metabolic pathways differ as well, including those for glutamate and vitamin B1230
Schizophrenics also have significantly higher amounts of Lactobacillus phage phiadh, a microorganism associated with a higher risk for diabetes, than healthy controls31
Those with bipolar disorder or schizophrenia tend to have chronic low-grade inflammation, associated with gut dysfunction and an imbalanced gut microbiome
People with bipolar or schizophrenia also have elevated levels of antibodies against Saccharomyces cerevisiae, a yeast associated with Crohn’s disease. Many are also sensitive to lactose and gluten, which can trigger inflammation32
Individuals hospitalized with acute mania have increased exposure to antibiotics.33 While the authors suggested this finding means these patients tend to have higher rates of bacterial infections, this link could also point at the hazards associated with killing off your microbiome with antibiotics, which decimate both good and bad bacteria without discrimination