Cannabidiol Improves Cognitive Impairment and Reverses Cortical Transcriptional Changes Induced by Ketamine, in Schizophrenia-Like Model in Rats

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In this study they used 7.5 mg/kg in adult rats who were given ketamine (not a neurodevelopmental model).

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If only my cognitive issues were because I was on ketamine. Or if only I were on ketamine and didn’t care about my cognitive issues.

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Ketamine is used sometimes to create SZ model rodents by giving it during development (which is a developmental model) or in adult rodents, where it still creates some schizophrenia like symptoms, but isn’t a developmental model.

It is probably useful to model NMDAR hypofunction either way though.

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What is ketamine?

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It is an anesthetic with dissociative effects. It is a NMDAR antagonist. In humans and mice it mimics some schizophrenia symptoms.

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So ketamine causes schizophrenia?lol

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No, but it mimics some of the symptoms.

Although you would probably not want to take it if you had schizophrenia or schizophrenia risk factors.

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So cbd is good for schizophrenia? I’m an avid cbd flower user.

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There are some human trials that have positive results, but it’s not yet conclusive. There will be more trials ending in 2020, 2021 and 2024. I would say it looks pretty good but we’ll see.

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