Potentially repurposable drugs for schizophrenia identified from its interactome

Drugs that targeted the same genes as the shortlisted drugs, have also demonstrated clinical activity in schizophrenia and other related disorders. This integrated computational analysis will help translate insights from the schizophrenia drug-protein interactome to clinical research - an important step, especially in the field of psychiatric drug development which faces a high failure rate.

The top 5 drugs by the score of anti-correlation are cromoglicic acid, bepridil, acetazolamide, dimenhydrinate, cinnarizine, of which bepridil and dimenhydrinate may be excluded due to their side-effects related to nervousness and hallucinations (see Table 1), thus leaving cromoglicic acid, acetazolamide and cinnarizine as top candidates.


Interesting that this drug is available OTC as a nasal spray for allergic rhinitis. (NasalCrom in the US).

There’s already a clinical trial in SZ: