Highlights
•Epidemiologic studies demonstrated an increased risk of psoriasis among patients with schizophrenia. However, the results are inconclusive.
•This meta-analysis of cohort and case-control studies demonstrated a significantly increased risk of psoriasis among patients with schizophrenia with 83% excess risk.
•The pathogenesis of this association remains unknown. Immune dysregulation, the susceptibility genes among psoriasis and schizophrenia may play a role in the pathogenesis.
•This study will raise awareness of the increased risk of psoriasis among patients with schizophrenia.
Abstract
Recent studies have suggested an increased risk of psoriasis among patients with schizophrenia although the results are still inconclusive. This systematic review and meta-analysis of cohort and case-control studies that compared the risk psoriasis among patients with schizophrenia versus subjects without schizophrenia was conducted to better characterize the risk. Pooled relative risks and 95% confidence intervals from the included studies were calculated using a random-effect, generic inverse variance method of DerSimonian and Laird. After a comprehensive literature review, 2 retrospective cohort studies and 4 case-control studies with approximately 6.1 million participants were identified. The meta-analysis found that the risk of psoriasis among patients with schizophrenia was significantly higher than non-schizophrenia subjects. Subgroup analysis by study design revealed a significantly higher risk in both cohort study and case-control study subgroup.
http://www.psy-journal.com/article/S0165-1781(17)30905-8/fulltext
http://sci-hub.cc/10.1016/j.psychres.2017.11.021