Older article about glycine and homocysteine

They hypothesized that altered glycine and homocysteine levels may contribute to N -methyl-D-aspartate receptor dysfunction and thereby influence the pathophysiology of schizophrenia.

Plasma glycine levels were significantly lower in the patients with schizophrenia than in controls, with values in male and female patients being 15.0% and 14.3% lower than healthy men and women, respectively. A difference in the ratio of glycine to serine between patients and controls was also highly robust.

In contrast to these low glycine levels, patients with schizophrenia also had high levels of homocysteine, which were higher overall for men than for women. Indeed, homocysteine levels in male schizophrenia patients were 65% higher than in healthy males, while female patients had levels that were 25% higher than those of control women.

This was also found in first episode psychosis (unmedicated).

B12, folate and NAC may reduce elevated homocysteine.

It seems to be important to take B vitamins together with NAC, if you do take NAC.


Some more:

compared with patients with normal plasma Hcy levels, those with high Hcy levels had more severe psychopathology manifested by high scores in PANSS-negative symptoms [26.14 (8.32) vs. 14.13 (7.43), P <0.001], PANSS-general psychopathology [32.15 (9.41) vs. 24.15 (11.43), P <0.001], more severe depressive symptoms [19.11 (7.98) vs. 9.46 (6.32), P <0.0001], and more impairment in social cognition assessment in the patient-rated version [38.11 (9.87) vs. 29.16 (10.41), P <0.003] and the caregiver-rated version [41.32 (11.56) vs. 30.12 (9.86), P <0.004].

The main results of this study are as follows: (i) First-episode schizophrenic patients are characterized by higher plasma Hcy and lower levels of folate and vitamin B12 compared with healthy control participants. These findings cannot be attributed to differences in age, BMI, or cigarette smoking in age as associated or causal factors. (ii) Patients with baseline high Hcy showed more severe psychopathological manifestations, more depressive symptoms, and a more deteriorating social cognitive performance than patients with normal Hcy levels. (iii) High Hcy levels at index hospitalization may predict a less favorable outcome over a 1-year follow-up period.


TMG produces SAMe used for methylation - one of the last steps in producing serotonin which helps with mood issues, depression, high anxiety, panic attacks, and OCD.