New guy looking for advice

SzAdmin · April 2, 2015, 6:24pm

Here is a meta study of all the studies of sarcosine and related supplements that focus on the NMDA receptor in the brain:

Results were based on a total sample size of 1253 cases from 29 trials that fulfilled the specified criteria.

CONCLUSIONS:

Taking into consideration the number of trials and sample size in subgroup analyses, D-serine, NAC and sarcosine as adjuncts to non-clozapine antipsychotics have therapeutic benefit in the treatment of negative and total symptoms of chronic schizophrenia. While glycine improves positive and total symptoms as an adjuvant to non-clozapine antipsychotics, it worsens them when added to clozapine.

ncbi.nlm.nih.gov

Meta-analysis of the efficacy of adjunctive NMDA receptor modulators in chronic schizophrenia.

SP Singh and V Singh, CNS drugs, Oct 2011 01

Based on the glutamatergic NMDA receptor hypofunction theory of schizophrenia, NMDA receptor modulators (NMDARMs) may have therapeutic potential in the treatment of schizophrenia.This meta-analysis aimed to evaluate the potential of modulators of the NMDA receptor as adjunctive therapy for schizophrenia, using the results from published trials.A primary electronic search for controlled clinical trials using NMDARMs in schizophrenia was conducted on the PubMed, Cochrane Library, EMBASE, CINAHL® and PsycINFO databases. A secondary manual search of references from primary publications was also performed.Inclusion criteria were the application of an established method of diagnosis, randomized case assignment, comparison of NMDARM add-on therapy with placebo, and double-blind assessment of symptoms in chronic schizophrenia using standardized rating scales. Results were based on a total sample size of 1253 cases from 29 trials that fulfilled the specified criteria.Scores on rating scales or on their relevant subscales were obtained for all selected studies from published results for the minimum dataset to compute the difference between post- and pre-trial scores and their pooled standard deviation for NMDARM add-on therapy and placebo groups for negative, positive and total symptoms.A negative standardized mean difference (SMD) indicates therapeutic benefit in favour of NMDARM add-on therapy and all SMD results mentioned here are statistically significant. The overall effect size for NMDARMs as a group was small for negative (SMD -0.27) and medium for total (SMD -0.40) symptoms of chronic schizophrenia. Subgroup analysis revealed medium effect sizes for D-serine and N-acetyl-cysteine (NAC) for negative (SMD -0.53 and -0.45, respectively) and total (SMD -0.40 and -0.64, respectively) symptoms, and for glycine (SMD -0.66) and sarcosine (SMD -0.41) for total symptoms. As adjuvants to non-clozapine antipsychotics, additional therapeutic benefits were observed for NMDARM as a group (SMD -0.14) and glycine (SMD -0.54) for positive symptoms; D-serine (SMD -0.54), NAC (SMD -0.45) and sarcosine (SMD -0.39) for negative symptoms; and NMDARM as a group (SMD -0.38), D-serine (SMD -0.40), glycine (SMD -1.12), NAC (SMD -0.64) and sarcosine (SMD -0.53) for total symptoms. When added to clozapine, none of the drugs demonstrated therapeutic potential, while addition of glycine (SMD +0.56) worsened positive symptoms.Taking into consideration the number of trials and sample size in subgroup analyses, D-serine, NAC and sarcosine as adjuncts to non-clozapine antipsychotics have therapeutic benefit in the treatment of negative and total symptoms of chronic schizophrenia. While glycine improves positive and total symptoms as an adjuvant to non-clozapine antipsychotics, it worsens them when added to clozapine.

anon40540444 · April 2, 2015, 6:36pm

The standardized mean difference coefficient for sarcosine is less than 0.60. Not a resounding victory. It MAY have some impact, but this “meta-analysis” does not mention length of symptom relief or abatement.

Csummers · April 2, 2015, 6:49pm

All right you two!
(just joking…)

The saying “It won’t hurt to try it” applies here,
and if it don’t seem to help, then stop.
Okay?

Now,
on with the business of welcome.

Hello @blades8922!
Welcome to our humble site, this is just a prieview of more to come.
Hopefully, all will post and be friends,
if not,
then at least be civil and supportive.

Post and reply often for best results.

darksith · April 2, 2015, 11:08pm

thought i would say hi.
take care

mister_lister · May 14, 2015, 12:48am

nice post consummers summer time
so, you are fed,
up to what point?

moto999 · October 2, 2017, 8:17am

Hi ,i suffer from mental health can sarcosine added to food then cook ?