New antipsychotic meds with supposed low side effect profiles

Medications
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  1. Lumateperone (iti-007)
  2. Roluperidone (min-101)
  3. SEP-363856
  4. KarXT

So the future looks a bit better for schizophrenics if they all make it to market.

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Do you know how they work like are they dopamine antagonist or partial dopamine agonist…?

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The idea for taar1 agonist popped in my head before I saw it in the sep medicine. I am really wondering if I’m crazy or not lol how does an idea pop in your head and then come to fruition in clinical research

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I don’t know how they work :frowning: Maybe they target dopamine indirectly. But I don’t know.

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Lumateperone is both, it’s supposed presynaptic agonist or something but it’s so good that it doesn’t even make you pace your house in circles all day like risperdal can make you do

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I really hope at least some of these make it to market. I’m running out of options and would love to try some of these when my current meds inevitably stop working.

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I hope they make it to market. We need more medication options.

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I think lumateperone has allready been approved.

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Yeah, lumateperone has already been approved.

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SEP is the one I’m hoping pulls through.

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Here is the list of all antipsychotics in developement.

Some interesting stuff. I hope a lot of these meds get approved so we could have better opportunities in fighting this illness.

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lumateporone is one I brought to my doc’s attention. She’s never heard of it, it can’t be looked up by our healthcare system Mercy. But she put it on her little inhouse reminder program so that she’ll hopefully get info on it asap. She said it’s so stupid that Mercy doesn’t let them know about anything FDA passed, unless they get samples from the company. And they’re not allowed to even give out the samples. But my pdoc used our phones to go outside her work computer to read the info we had on it. She said once she’s “allowed” by Mercy I’ll be getting RXed it.

She is not thrilled that her office is not doing everything they can to keep up, but they are told their newest drug to push is Vraylar…allergic to it! She said that they’ve had 3 people have the same reaction I had to that, from that pdoc I fired for just upping it and telling me to suck it up and take 16 benadryl a day. ■■■■■. But my pdoc now at least respects me and my health.

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I’m looking forward to Karxt. I want something really effective that also won’t give me a ■■■■ ton of EPS like all the other meds.

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Lumateperone has very low D2 activity. It peaks out around 40% at the usual dose and rapidly diminishes through the day - that is probably why it doesn’t have the same side effects as others that are in the 60-70% range.

MIN-101/Roluperidone acts on serotonin and sigma receptors. No known direct dopamine action.

SEP-363856 acts on TAAR 1 and probably others. Although it does not block dopamine, in mice it normalizes presynaptic dopamine synthesis. So rather than block it after the hope is to make as normal an amount as possible in the first place.

KarXt is an M1 and M4 agonist with a blocker to prevent the peripheral side effects it would cause otherwise.

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Thanks @twinklestars, that’s helpful.

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