I was comparing how different antipsychotic affect each receptors and according to wiki Lumateperone only affects 3? Is this correct?
5HT2A, d1 and d2 receptors?
Compared to abilify the med I am on which seems to affect over 20… is less better? Or is it just that we don’t know yet if lumateperone affects more receptors?
I don’t do good on partial dopamine antagonists like Abilify and Lumateperone. I am waiting for KarXT (Xanomeline). Its the best for negative and cognitive symptoms:
I don’t know how I feel about taking something that supposedly increases cognitivy… but I know the “negative” symptoms for me come from the antipsychotic itself
Why do you say that? For me it’s mostly libido so I guess it is related somewhat to dopamine? And Lumateperone peak d2 dopamine antagonism is only 40%…how does it compare to Abilify?
Its Xanomeline that you’re talking about not KarXT. KarXT is Xanomeline+Tropsium which has no side effects at all vs placebo. Tropsium suppresses Xanomeline’s side effects by blocking Xanomeline’s effects in the spinal cord. You can read about KarXT clinical trials 2 which have no side effects and still successful: