It annoys me when people such as pdocs say the negative symptoms are part of the disease. I am certain that motivation problems come from the drugs.
This is an old study which shows that negative symptoms can appear from first time administration of haldol and risperidone to healthy people.
This is just after one use. I would like to see what they were like after three months.
JF Artaloytia, C Arango, A Lahti, J Sanz, A Pascual, P Cubero, D Prieto and T Palomo,
The American journal of psychiatry , Mar 2006
Despite the clinical observation that antipsychotics can produce negative symptoms, no previous controlled study, to our knowledge, has evaluated this action in healthy subjects. The present study assessed observer-rated and self-rated negative symptoms produced by conventional and second-generation antipsychotics in healthy volunteers.The authors used a double-blind, placebo-controlled trial of single doses of haloperidol (5 mg) and risperidone (2.5 mg) in normal subjects. Thirty-two subjects were administered haloperidol, risperidone, and placebo in a random order. Motor variables and observer-rated negative symptoms were assessed after 3-4 hours and subjective negative symptoms and drowsiness after 24 hours.Neither of the active drugs caused significant motor extrapyramidal symptoms after administration. Haloperidol caused significantly more negative signs and symptoms than placebo on the Scale for the Assessment of Negative Symptoms (SANS) and two self-rated negative symptom scales: the Subjective Deficit Syndrome Scale total score and an analog scale that evaluates subjective negative symptoms. Risperidone caused significantly more negative signs and symptoms than placebo on the Brief Psychiatric Rating Scale (BPRS), the SANS, the Subjective Deficit Syndrome Scale total score, and the analog scale for subjective negative symptoms. After control for drowsiness, risperidone but not haloperidol produced more negative symptoms than placebo on the BPRS and the SANS. Significance was lost for the subjective negative symptoms with both drugs.Single doses of both haloperidol and risperidone produce negative symptoms in normal individuals. Drowsiness may be an important confounding factor in the assessment of negative symptoms in antipsychotic trials.
3 Likes
Simonw
March 19, 2019, 11:00am
2
Some medications definitely seem to make me more lazy, I am not sure if they are negative symptoms.
I saw my psychiatrist today who stated that low motivation can sometimes be a side effect of the drugs. For me it seems to be a combination - drugs and negative symptoms. No matter what the cause is, it is very annoying.
It’s the most irritating point for me. Stops me from going outside and engaging with people and activities. I’m lucky that the drugs fix my positive symptoms, although I would take some very low delusion if it meant I was motivated.
I had negative symptoms well before I was on meds. But yes, I do believe medication can contribute to lack of motivation. Which makes sense, since the meds mess with dopamine.
I agree. I had some before the meds, namely social withdrawal, but motivation was never one of them.
1 Like
Then I think it’s safe to say meds either enhanced it, or they just flat out caused it.
system
June 17, 2019, 11:13am
8
This topic was automatically closed 90 days after the last reply. New replies are no longer allowed.