N-acetylcysteine as a new prominent approach for treating psychiatric disorders

Well, I tried it and it interacted with Abilify and made Abilify less effective and I had suicidal ideation on it.

But if you’re not on Abilify then maybe you should try it.


Looks like N-acetylcysteine (NAC) is one of the precursors to glycine. So NAC probably works the same pathway as all those glyt1 (glycine transporter 1) inhibitor drugs coming out.

I did a little digging and found this paper though N-acetyl cysteine treatment rescues cognitive deficits induced by mitochondrial dysfunction in G72/G30 transgenic mice - PubMed

It makes me wonder if mitochondria have a role in SCZ Mitochondrial dysfunction in schizophrenia: an evolutionary perspective - PubMed

Mitochondria are involved in metabolism and energy. I know personally that if my food/glucose/insulin is off it’s much harder to cope with my SCZ symptoms. As a result, I come across as less functional when my food/glucose/insulin game is off.

So I definitely believe there could be a connection between mitochondrial dysfunction and SCZ.