"Quetiapine fumarate is an atypical antipsychotic that has been shown to have both remyelinating and neuroprotective properties "
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674562/#!po=25.1553
What are the practical implications for schizophrenia sufferers?
Do you have concrete recommendations for persons ill with schizophrenia?
@twinklestars
Thank you very much for posting!
This again points to the fact scientists are enable to properly diagnose sz. They simply lump it all in. We should at least get cleared by our pdocs for some forms of sz (MS related, NMDA, …). We are just sz and put on APs. Doctors can go ■■■■themselves for being retards. I used to have 140+IQ. I can’t even work anymore.
There is a clinical trial on that (MS and quetiapine). 300mg is the dose used. And here I thought APs were neurotoxic.
I can’t make medical recommendations, but there are some simple healthy strategies to increase remyelination; exercise, learning new things, sleep, fish oil and other vitamins. This is a more exhaustive list:
Someone was asking about meds specific for delusions, and there aren’t any that I know of, but if indeed they are associated with demylenation, quietapine might help, that would be a question for your pdoc and also people here, did it help their delusions?
I agree, more work must be put into biomarkers to identify most useful medicines for each person - at least until a better option is found.
Naturally, people quit meds regularly, not only do they have side effects, but if you’re on the wrong one they don’t work very well. Doctors consider several failed trials of meds to be acceptable (in fairness, they don’t have readily available biomarkers) but each failed med trial increases the risk a patient will end treatment, or hurt themselves or others. There are a few researchers working on this. As whole exome sequencing, brain scanning, and proteomics become cheaper and more widely used, it’ll become easier to find the right med for each person.
“Taken together, “potential treatments for delusions in schizophrenia could aim to both increase myelination and reduce neuroinflammation and atrophy in the cingulum bundle, which would require polypharmacy,” the authors concluded.”
From the article above on delusions in sz.
I wouldn’t hesitate to print the article out and take to your doctor, because they can’t possibly read every sz related paper and still have time to see patients.
I didnt read it all but i think they are getting closer to something because Myelin is part of the Glail cell, I was just looking this up the other day very interesting.
I just saw a new study about some type of histamine that had shown promise with potentially curing MS. I wonder if that could transfer to those specific sz cases. That would be really interesting. I’ll see if I can find the article I saw.
The phase II trial showed promise recently, but I couldn’t quickly find the article I read. But here’s an older one that still explains the gist of it.
Nice, heres a link to a study in mice for schizophrenia using Clemastine
“Our findings suggest that myelin repair can be achieved even following prolonged damage.”
Good news for MS, and possibly sz and other diseases.
That is interesting, I used to take Tavist (clemastine), it was a very long time ago though.
I found clemastine on a list of drugs that can cause symptoms of sz.
Taking it with a grain of salt, because it also says benzos can cause symptoms of sz, and if they do, it’s clearly not common.
benzos cause symptoms in me after about a week, so i wouldnt be surprized if clemastine might too