It is only beginning phase 3, many drugs which were a sure thing have failed phase 3. And if this sigma receptor is so good why hasn’t fluvoxamine cured everyone of their negative symptoms? To repeat, 5ht2a antagonism has been tried already, all the atypicals do this.
Everything helps a little in trials, we need a targeted therapy which blows negative symptoms out of the water.
All the discoveries @firemonkey posts on this forum seem to lead nowhere. it has been the same for years…
I really can’t answer your question @eduvigis
All I know is that new medicine always have unexpected results. In theory min-101 deals with 5ht2a and sigma receptors, but maybe it does something extra too, something that’s yet to be discovered. As long as clinical trials suggest an improvement in negative symptoms, that’s enough to comfort me 
Yes, it might not “blow them out of the water” but even a 20% improvement could change my life for the better.
@eduvigis You don’t realize the gravity of the problem, in a post you wrote that schizophrenics
lose 10-20 IQ points when in fact lots, perhaps most lose their entire iq!
I for example can’t function at all cognitivey.
I feel like I lost my entire IQ, way more than 100 points.
All our psychiatrists are all taught in school that negative and cognitive symptoms come from hypoactive dopamine neurotransmission in the mesocortical dopamine pathway. Yet aripiprazole and the partial agonists rarely cure negative symptoms, sometimes they make them worse. If it is just an issue of not enough dopamine in this pathway can’t we just find some indirect or direct way of increasing dopamine in there. Are our psychiatrists being taught lies or an oversimplification of the truth–a WAY oversimplificaiton?
So many people are suffering, myself being one of them. I think it is way overdue for us to find a way out.
All I can do is post the research as I find it. How it pans out is beyond my control. Trying to hone in on stuff that works is a complicated and lengthy process for the researchers.
False starts are frustrating but better some false starts in looking for solutions than no attempts at all.
Erez, I have also lost huge parts of my cognitive functioning, if only a treatment could be discovered which could reactivate the parts of my brain which seem to have died off…
I concur. My pdocs have also mentioned low dopamine in the prefrontal cortex. I am aware that abilify which I am taking doesn’t deal with my negatives at all. So perhaps they are being taught lies, yes, but not purposely. The hypodoparminergic theory still has many supporters.
All in all, we are expecting a radical breakthrough in the understanding of negative symptoms. It may take decades, but in the meantime we put our hopes in little crumbs like min-101
If you’d lost all your IQ you wouldn’t be posting here. You’d be in an adult baby chair at meal time being spoon fed.
I’m just waking up, so forgive me if this doesn’t make sense.
What stands out to me is the increase in calcium in the brain. This should elevate mood, make us more social, improve sleep to the point of delta waves (REM), improve memory and cognition.
I hope so.
@firemonkey first of all, there are schizophrenics (many) who are exactly like you described.
I feel that I suffer hugely cognitively.
I have met people who were “adult babies” in the hospital. Sometimes its not that the IQ is gone, they just cant access it because they have issues with executive funcitoning, in other words their brain has lost its connections. Or they have a 2 second attention span. Or they have voices screaming at them 24/7 which distract them, schizophrenia disrupts IQ in many different ways.
It seems I have high dopamine in the prefrontal cortex as a met/met. It’s supposed to give better cognitive functioning unless under stress.
Yes, my point is that in many( and perhaps most) cases the damage is much more profound than 10-20 IQ
points as you wrote in a post.
It is bad to belittle the gravity of the problem since it reduces the motivation of researchers to advance
better treatments(@eduvigis)
Whilst I have no doubt you have cognitive issues(many of us with severe mental illness or ASD do) it doesn’t help to be too negative about such things.
You are posting here so whatever your cognitive difficulties they are not as severe as those with sz totally unable to post on a forum such as this.
When I was first out of the hospital I had severe cognitive symptoms, It would have been a struggle to do simple arithmetic. After some time I recovered, I recognize that I still have lost 10-20 IQ points, but the atypicals I am on help a little. Seroquel is supposed to improve sustained attention (I had the attention span of a squirrel for months), Rexulti is supposed to be procognitive and increase dopamine metabolites in the prefrontal cortex (helps with cognition in rats). I am still ashamed to say that my 19 year old self was superior to my 21 year old self when it came to mental capacities in every way.
I am posting here but that is the only thing I do.
I am very low functioning and you shouldn’t deduce from me posting here that I can do other things as well.
I can’t work, study, cook, I can’t solve puzzles my capacities are very limited.
It is true that many are even worse off than me, on the contrary I try to raise awareness
of their plight.
I have no doubt you are right. However no one currently posting here will be at “adult baby” level. That is not to say we will not have some problems with things like executive functioning, slow processing speed etc(I certainly do) but they don’t place us as “adult babies”.
I think the subgroup we have on this forum selects out people who have more motivation, less cognitive deficits and so on . When I am in the hospital I meet people who never go home, totally dysfunctional, some being spoon fed.
There were different types of people in their, many just couldn’t keep off of drugs. The schizophrenics definitely fit the rule of thirds or whatever. Many were severely disabled, for many it is like a brain injury almost, like a stroke or an aneurysm. Sz can be mistaken for traumatic brain injury.
@eduvigis very well, you are relatively lucky.
You should remember to show empathy, and not to describe the disease as the loss of just 10-20 IQ points,
this is unfair,in many perhaps most cases the damage is more profound,
please don’t belittle the damage this disease does to the brain, as you said there are adult babies,
people in a very bad state, it is wrong to write off this atrocious disease as just the loss of 10-20 IQ points.
You are a very very lucky man , but you should remember that many are not as lucky as you.
I mean no offense, I just dislike it when people who are relatively fine belittle the plight of those
who are worse off.