Med for alogia (poverty of speech)

Medications
1

Do you guys know some med for alogia (poverty of speech)? Is there treatment for it?

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I don’t know of a med but if you don’t have problems reading, reading aloud to yourself for 10-15min a day might help.

3

When I first started gabapentin I got very talkative.

4

I have really bad alogia, you could try an alzheimer med called galantamine, its supposed to help with alogia.

I bought some online and I’m about to try it.

I know you’re already on abilify, Abilify is supposed to be good for verbal fluency. If it hasn’t worked for your alogia try other things.

Clozapine is good for verbal fluency.

If you have the MFHTR mutation folate and vitamin b-12 supplementation could cure your alogia. Heres a quote:

“n the new study, first author Joshua Roffman and colleagues explored folate’s effects in a larger sample, and considered variants within genes encoding multiple folate-related enzymes: folate hydrolase 1 (FOLH1), methionine synthase (MTR), catechol O-methyltransferase (COMT), and MTHFR. Using a randomized, double-blind, placebo-controlled design, the study tested the effects of daily intake of 2 mg of folic acid and 400 μg of vitamin B12, which enhances folate’s actions. Of the 140 people with schizophrenia enrolled in the trial, 94 were assigned to folate plus vitamin B12 and 46 to placebo; 121 completed the trial.
Sixteen weeks later, negative symptoms had not improved significantly in the folate group as a whole, but there was a significant finding when genotype was taken into account. Among those carrying two copies of the 484T allele in FOLH1, folate reduced negative symptoms compared to placebo by an average of 0.59 points per week on the Scale for the Assessment of Negative Symptoms (SANS). In contrast, no significant difference was found between folate and placebo among 484C allele carriers. For the MTHFR genotype highlighted in their previous study, the difference between folate and placebo missed statistical significance (p = 0.17). The improvements stemmed largely from reductions in alogia, a poverty of speech.”

So get checked for that mutation and folate supplementation might cure your alogia.

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5

Thanks for the answers. I will ask my doc about galantamine and folate. My doc said it’s okay to take complex b vitamins, so I will take them again.

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I don’t know if I have MTHFR mutation. Is there an exam for it?

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I don’t know one person on this website said they had a test. I’ll have to talk to the pdoc about it see if he has the info.

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I don’t know if it’s me but any drug I have tried for alogia has either crapped out or has short half-life, leading to me taking it throughout the day.

  1. Maprotilline (kind of works, yet you have to find the right combination of AP + Maprotilline for it to work; plus it made me really angry and exacerbated my positive symptoms);
  2. Memantine (worked for ~9 hours a day, but I think it crapped out after 10 days on it, although I’m not 100% sure);
  3. Coffee and energy drinks (various forms; work for various periods of time – from 1 to 5 hours; I think it craps out for me from time to time, although, again, I cannot be sure as I change meds pretty frequently; could be interaction)
  4. Sertraline, a moderate DAT inhibitor, improved my talkativeness although it came with nasty side effects such as anger, irritability and feeling too energetic. It’s a risk/benefit ratio.
  5. Sarcosine which is the safest of these substances, worked pretty similarly to caffeine (1-6 h), with added benefit of improved mood and sociability; call me crazy but I think the usual dose I was taking crapped out after 6 weeks and I had to up the dosage; not sure what can be made up of this.
  6. Various other substances that work at NMDAR receptors; with the exception of sarcosine, described above, they can be pretty spotty, in that sometimes they work and sometimes don’t; but possible as an augmentation therapy, if combined with other NMDAR agonists.
1 Like
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Sorry abit offtopic but this came to mind.