Long-Acting Antipsychotic Delays Schizophrenia Relapse Longer Than Pills

The long-acting, injectable antipsychotic Invega Sustenna (paliperidone palmitate), which is given monthly, was found to be effective for six months longer than oral antipsychotics commonly prescribed for schizophrenia, according to a study conducted by the drug’s manufacturer, Janssen.

The PRIDE (Paliperidone Palmitate Research In Demonstrating Effectiveness) study enrolled 444 people in a 15-month, prospective, randomized, open-label, active-controlled study. Patients were randomly given either Invega Sustenna (78–234mg) or one of seven flexibly-dosed, common daily oral antipsychotics: aripiprazole, haloperidol, olanzapine, paliperidone, perphenazine, quetiapine, and risperidone.

The primary endpoint was time to first treatment failure or relapse. Invega Sustenna delayed relapse for a median of 416 days, compared to a median of 226 days with oral antipsychotics, according to study results published The Journal of Clinical Psychiatry.

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I’m still going strong! High five*

Its obvious that an injectable is going to last longer. What you don’t understand is that these drugs can put you through a really bad time. @SzAdmin you don’t take drugs yet you push them, if only you would know the truth for some inderviduals that they are very unpleasant.

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No question - the drugs that we have today are far from perfect.

But - its also undeniable that they help a lot of people, most people in fact, who have schizophrenia. I recommend you read this:

Check out this recent poll of users on our site before you being too critical of medicine:

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Isn’t that the point of long acting antipsychotics?

Yes - from that perspective, no surprise I guess.