Investigation of betaine as a novel psychotherapeutic for schizophrenia



Betaine (trimethylglycine) functions very closely with choline,folic acid, vitamin B12, and a form of the amino acid methionine known as S-adenosylmethionine (SAMe)

Food sources include beets, wheat bran, spinach and quinoa.

Furthermore, a CHDH variant, rs35518479, was identified as a cis-expression quantitative trait locus (QTL) for CHDH expression in postmortem brains from schizophrenia, allowing genotype-based stratification of schizophrenia patients for betaine efficacy.

Well I guess that’s something to look into for those who have had their genome sequenced.

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Thanks for sharing. I am interested in learning if betaine (Trimethylglycine) TMG could be as effective as sarcosine. Does anyone know? Has anyone tried Betaine?


I have been taking TMG (betaine) for a while now, 2000mg every four hours or so during the day. Seems to be a nice mood brightener. I don’t see any effect on positive symptoms though. Much clearer of an effect than sarcosine, which I got tired of really quickly due to it’s ‘dirty’ feeling…