Inflammatory biomarkers may influence schizophrenia risk

"An association between schizophrenia and the immune system was suggested more than a century ago. Infections during pregnancy and early childhood, as well as autoimmune diseases, have been linked to an increased risk of schizophrenia. In addition, findings from the largest genome-wide association study of schizophrenia to date corroborate that immune dysregulation plays a role in the pathogenesis of schizophrenia,” Fernando Pires Hartwig, MSc, of Federal University of Pelotas, Brazil, and colleagues wrote.

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What’s that saying? If an “elder statesman” of a scientific field says something is impossible, you may be sure that it is possible. If a young scientist says it is possible, you may be sure it is possible.

Since sz is not a spiritual issue but a physical one, it affects the body, this can be measured, we just don’t have a good way to do that reliably yet. Also it may not be realistic to have only 1 marker in a heterogeneous disease, like testing hemoglobin levels as a marker for iron deficiency, it’s more complex.

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“Under mendelian randomization assumptions, our findings suggest a protective effect of CRP and a risk-increasing effect of sIL-6R (potentially mediated at least in part by CRP) on schizophrenia risk. It is possible that such effects are a result of increased susceptibility to early life infection.”

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