In conclusion, we have demonstrated the causal associations between several immunophenotypes and SCZ through a comprehensive bidirectional MR analysis, highlighting the complex pattern of interactions between the immune system and SCZ.
Furthermore, our research significantly reduced the impact of unavoidable confounding factors, reverse causality, and other factors. It may provide a new avenue for researchers to explore the biological mechanisms of SCZ and can lead to exploration of earlier intervention and treatment. Our results extend the findings of psychoimmunology, providing valuable clues for the prevention of SCZ.
Very good question, I wouldn’t know but my guess would be that researchers think so since they trail medications with anti-inflammatory properties. Minocycline and Celecoxib come to mind but are unproven and don’t have a good evidence base this research is a space to watch.
Even if they are overactive in maintaining a disease state, it is another question if this process be reversed through mediation or is it just chronic once initiated. Maybe it can be reversed but we just don’t have current medications and therapies which can treat this. Until you see therapeutic effect you don’t really know for sure if this is driving the disease process. This is how we proved antipsychotics worked.
Neverless inflammatory processes are definitely implicated, that could still be upstream or downstream of other bigger issues though.
