I don’t know if it’s a direct cause of my full-blown psychotic episode last year or Latuda is. I’ve become (up to extreme) impulsive and careless on Latuda. One way this is positive but because I’m also fighting emotional stress/depression (periodic mood swings) at the same time I can be so self-destructive and don’t give a ■■■■ about what I’m doing and the consequences of what I’m doing. Like right now, I’ve become gamble addicted, whereas in the past I could let it go because I’m not a real addict, (just have the tendency towards), and my addiction would be triggered when really sad but this time I’m not sad, just really stressed but I can’t guide myself (which I could in the past) to correcting my behaviour towards myself again, like that part of me is “missing”. Because I can’t find a psychological link with my past behavior with addiction I’m starting to get convinced Latuda is causing this personality changes. Latuda is the best antipsychotic I’ve ever taken so switching is not an option. Anyway, I’m not here to vent actually, does someone else notices personality changes like impulsitivity, addiction and carelessness on Latuda? And oh yea, with carelessness I also mean I became some sort of a egoistic jerk, just like the average “normal” human being (which has it’s pro’s and con’s)
My experience with Latuda so far is that it makes my psychosis almost completely go away, and also helps keep horrible intrusive thoughts away, but yes, it also makes me feel agitated and hypomanic. I have a previous diagnosis of bipolar disorder so I might be sensitive to the serotonin effects of Latuda, I don’t know. I would prefer a mood stabilizer and anti-depressant but unfortunately I have to be on an AP for psychosis, and with no mood stabilizer I think that yeah it causes some hypomanic symptoms for me.
That’s my point to for not switching Latuda, almost positive symptom free and no intrusive thoughts! I’m became antidepressant free because of Latuda, though, thinking about throwing an antidepressant in the mix, that might be an option to see how I react to it and who knows it might clear some self-destructive behaviour I’m struggling with right now.
I’m slooooowly getting the hang of alerting my pdoc upfront when I’m having problems. It’s the best thing to do. I’ve always had a hard time with it because I know if they dismiss my concerns, I will get super pissed, and I’m afraid of me being super pissed because I get that borderline psycho rage sometimes. BUT it’s the right thing to do, keep the pdoc informed and discuss med plans / side effects with them.
Yes, though, never resist a fight against them or they will just not listen or throw ■■■■ down your throat which they think is best for you. If you fight, they’ll hear ya!
Sorry Latuda didn’t work for you. It can cause manic stages in bipolar
I know that Abilify can cause impulsive behaviour - triggering gambling sprees.
I was shocked to see a class action lawsuit commercial on TV against Abilify.
I guess Latuda can cause impulsive behavior as well.
One method of treating bipolar disorder we learned about in my class was to mix a mood stabilizer with an atypical antipsychotic. It’s not uncommon at all. Maybe talk with your pdoc about your concerns.
It’s good that you can sue them over such things in the US, in Europe we don’t even hear about those lawsuits! I thought about Latuda causing it but wasn’t sure so I overlooked it for too long. Now that I know I can inform and discuss this issue and look for a solution with my care providers.
During the short period of time that I was on Latuda I was always angry, but that could have been because I was withdrawing from Geodon and Seroquel.
I skimmed over the pharmacological mechanics of Latuda (Lurasidone) … The common denominator between impulsivity, carelessness and addiction propensity is sub-optimal dopamine nuerotransmission.
It’s a balancing act on a fine line between poor conscientiousness and a relapse of positive Sz symptoms.
Conclusion: It appears that the concentration of Latuda in your system exceeds the therapeutic range for your current physiology.
Exceeds…? Too much or to less Latuda in my system?
Makes me wonder… If the dopamine is too high this would cause psychotic symptoms, which I have just a little that just isn’t possible to get rid of on Latuda. OR… If it’s too less dopamine this will trigger gambling-sprees/impulsitivity to get my dopamine up. What’s the case?
I don’t want to blame Latuda alone because any drug you are taking that influences dopamine will be playing a part in this.
Too little dopamine = poor impulse control, careless behaviour, instant-gratification / thrill seeking, low will power/addictive magnetism etc. (so pretty much me. Hi! waves)
Too much dopamine (especially in SZA physiology) = a trigger to all the positive symptoms: hallucinations, delusions, racing thoughts etc.
It is no one else’s place to say “it’s better for you to have too little than not enough”, because quality of life is subjective and it is YOUR life and YOUR call. However, there is absolutely no harm in talking to your GP or PDOC in relation to these issues. They will immediately understand what I have concluded (I seriously, bloody hope!) and start thinking of safe solutions to trial.
Good luck and hang in there! Try to distract yourself while you feel so impulsive. Rhetoric: why do you you think I’m on here so much 
Latuda was a dream that turned into a nightmare. The dream part was that my voices came to a virtual end, I no longer felt uncomfortable in social situations, and I was almost not afraid to do anything. The bad side is i became hypomanic, a total jerk, talked all the time including when no one was talking to me, paced a lot, couldn’t sleep, had serious anger issues at times, was very happy but not really, and made a total ass of myself. It was quite a ride into a concrete wall.
Thanks for clarifying. So basically I’m suffering from too low dopamine. Right now we decided to throw Vortioxetine in the mix to see if that will affect me positively. If that doesn’t add any benefits I might lower the Latuda and see how that’ll work.
The behaviors described suggest as much and Latuda is an ANTagonist of dopamine, so the arguments are there to support the hypothesis, but I’m not qualified (I just like to act like a Dr. :D) to provide a conclusive response 
Certainly, it’s worth exploring though.
And what an unusual atypical AS this one is … it’s when I read pharmacomechanic profiles like this that I start to wonder if the pharmaco-chemists just throw ■■■■ in a pot and see what happens. lol
If the low dopamine behaviors disappear after Vortioxetine kicks in, just don’t rule out placebo. Serotonin dysfunction CAN lead to these behaviors, but more as a byproduct of being moody than seeking pleasure.
If you have a history of mania, check in with yourself while on Vortioxetine. I personally write logs - couldn’t hurt?
Let your treating pro know before-hand. I daresay you won’t need a huge reduction.
I don’t want you to think that I’m attempting to contradict you, but I’m struggling to understand the mechanism through which Latuda might induce mania in SZA physiology. Its purpose is inherently to reduce the activity on neurotransmitters/receptors that can lead to such things. That being said, I’m not the only one who doesn’t understand:
The mechanism of action of lurasidone HCl for the treatment of bipolar depression and schizophrenia is unknown. Its efficacy may be mediated through a combination of central dopamine D2 and serotonin type 2 (5-HT2A) receptor antagonism. Lurasidone HCl is an antagonist with high affinity binding at the D2 receptors and the 5-HT serotonin receptors 5-HT2A and 5-HT7 receptors.8
It could be hypomania-like symptoms resulting from the natural human response to experiencing relief from pervasive negative symptoms over time. Rather than an actual pharmacological cause for concern.
All this being said, if I were on Latuda I’d be making a point on checking in with myself regularly and involving others close to me in helping with that task. Losing insight is not a good path to start down.
What a ■■■■■■■ ride I’m in right now. If it wasn’t for smoking CBD, I wouldn’t realize. I slipped into pre-psychosis. Don’t know what role Latuda has played but I’ve been hypomanic for almost a month, ■■■■ hit the fan this past weekend. Although got to give Latuda credit, it’s a way better antipsychotic than Zyprexa.