Iclepertin update

Medications
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So I’ve either been on iclepertin or placebo since last Monday and if I had to guess I’d say I’m on it. The drug agonizes the NMDA receptor via the inhibition of the Glyt1 receptor which theoretically improves cognition by reducing glutamate. And that’s exactly what I feel. I feel sharper, more “with it”. The improvements are definitely modest but functioning with this disease has always been a game of inches for me so I’m hopeful I’ll be able to make some improvements in my life over the next year and a half while I’m on the drug. These improvements also have me very excited for evenamide which is another drug in clinical trials that modulates glutamate but apparently much more robustly.

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