I learned what happens on the schizophrenics brains and here it is

Medications
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So I learned what happens in sz brains. I will also talk about AP effects on sznics.

There are 4 dopamine pathways in the brain: mesolimbical, mesocortical, nigrastriatus, and tuberculoinfundibular.

The mesolimbical is related to the reward mechanism so action reward. Here is where sznics have excess dopamine that causes positive symptions

The mesocortical is related to cognition, memory, emotion, and we sznics have low levels of dopamine in this pathway. This pathway is responsible for the negative symptions.

The nigrastriuatus pathway is related to movement. dopamine levels on this pathway are not effected by sz. Low levels of dopamine on this pathway cause parkinsons.

The tuberculoinfundibular pathway dopamine levels are not affected by sz. This pathway has to do with the production of prolactine.

So basically we have hallucinations because we have too much dopamine in the mesolymbical pathway. reward mechanism of the brain. action then reward. We have negative symptons because we have low dopamine in the mesocortical pathway which is related to memory, emotions, and cognitivity.

The rest of dopamine distribution is just like in a normie.

AP decrease dopamine over the entire brain.

It solves positive symptions because it decreases dopamine in the mesolymbic pathway.

It worthens negative symptions because it makes dopamine levels already low into much lower in the mesocortical pathway: memory, emotions, and cognitivity.

It decreases dopamine in the nigrastratus pathway that is why AP overdose causes parkinsons. The other effect of this is extrapiramidal symptons such as stiffness, pointy extremities, and so on. The decrease of dopamine in the nigrastratus pathway causes akathaesia which to me was terrible for a long time.

AP decreases dopamine in the tuberculoinfundibular pathway which causes hyperprolactnaemia, excess of prolactine.

APs must decrease dopamine in the brain by at least 60% to solve positive symptons.

First generation APs such as haldol decreases overall brain dopamine by over 80% and thus the enhanced extrapiramidal effects. Passes 80% causes trouble moving, mouth dryness, stiffness, I had all of this with haldol to solve my first pshycotic ephisode. also terrible.

second generation APs add an inhibition to serotonine which causes the decrease of overall brain dopamine by around 70% not causing th extra piramidal effects. The rest is just like the first generation.

APs worthen negative symptons and anticholinergic drugs are prescribed to work on this but that is something else. Overall APs worthen negative symptons.

Akatheasia which to me was always terrible and prohibits pleasure absorcion is caused by low dopamine in the nigrastratus pathway. Too much AP and you get parkinsons.

Amenorrhea and galactorrhea are caused by hyperprolactinaemia caused by low dopamine on the tuberculoinfundibular pathway.

That is basically the history with us.

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I don’t normally read posts this long, but it’s interesting to know the mechanics behind it all.

What I want to know is what impact this AP thing has on the rest of our bodies

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AP 2nd generation drop serotonine levels. 80% of serotonine is located at the gastrointestinal tract and have important role in bowel movements. So, you can have constipation, generally your bowel works slower than normal. I have constipations. I eat a lot of fiber. That is one one effect of AP 2nd generation. Other than that akatheasia which is restlessness so you cant stay too long in the same place, you cant be engaged too long into nothing, and you dont have pleasure, i know because i had it for many years. I don’t know what it is about invega that does not give me that. because of the nigrastratus pathway low level of dopamine in the brain you can get movements like tapping, moving one part of the body like tappinbg your hand on your thie for example or moving the toes like i am doing right now. you can also get movement disorders like minor shaking of hands, feet, arms, stuff like that. you can get erectail disfunction due to the hyperprolactinaemia due to the low dopamine levels on the tuberculoinfundibular pathway. this low dopamine on the tuberculoinfundibular pathway affets women much more. you can get milk coming out of your nipples specially if you are on risperidone. also involuntary movements of the eye. or when having extrapiramidal effects you can get your eyes locked at looking up. sort of muscle contractions that wont go away. You can get orthostatic hypotension which is rapid drop of pressure when you get up from a chair for example. Weight gain. That is far as I remember right now. There might be more.

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You have a lot of typos in your thread and post. It would help if you fixed them. Then people can understand what you’re trying to say.

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I don’t have native english but I guess people can ultimetely understand it. Thanks. Appreciated.

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read some of this.

what about pain? the affects?

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pain perception is not related to sz. Pain can be decreased by opioids and antagonism of gaba receptors decreasing the level of pain communicating synapses along the spinal cord and the brain. But sz does not change how we process pain nor do APs. The pathways for brain pain perception are separate and not related to sz.

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What about those of us that have sz but do not have hallucinations?

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Same thing. I said hallucinations because they are part of the positive symptons. Read positive symptons where I wrote hallucinations

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@egofree, you’ve done a great job!
I mean it…

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Thanks zoa. I tried to break it down to as simple as possible as I have experienced all the symptons so it is nice to learn why.

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Yes, thanks…
Always wanted to know about where voices are placed…
Mine are terrible…

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Sorry to hear that. I used to have terrible voices all day everyday. But moving to a placeful place without city noises really help me up. Silence. No stress. Exercise.

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I didn’t know. Thanks. In my experience however I never felt any difference. Interesting theories.

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Thanks for the post. Learned something!

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Very interesting if accurate. Do you have a source for this information. I’m too lazy to verify it all.

I understood it even though English is not your native language.

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yes. i like to study medicine. last night i watched a video directed at phyquiatry students on the subject of sz and APs specially commented on most frequent questions on exams so very accurate stuff. that is what happens and how APs treate it.

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