How Schizophrenia Resembles the Aging Brain | Harvard Magazine

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I used to have a theory. The Brain can only take so much stress before the point of or onset of cellular aging occurs.

I’m gonna read this quickly, it sound similar!

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Interesting theory :face_with_monocle:

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Doesn’t really say, or I don’t know enough biology to understand the repercussions of the findings !

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My MRI was analyzed and everything came back normal. So IDK. I am not sure these aging brain / early dementia/alzheimers in schizophrenia are always the case.

I’ll either let you know in 10 years or forget to let you know in 10 years.

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I think it’s because it specifically targets certain genes in the tissue samples taken from the people. That’s why their research is more concise in terms of brain imaging than is typically the case

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That may be the case, but I scanned the article and it said that similar findings were found in MRI’s. Or something to that effect.

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Oh yeah, I saw that too

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McCarroll also pointed out that similar findings (such as cortical thinning and loss of dendritic spines of neurons) from MRI and other types of brain scans have been observed in patients with both Alzheimer’s disease and schizophrenia.

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Yeah, that’s it. I remember too.

Idk then, you’re right. I wonder what the reality is in most of our brains

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My MRI was analyzed, and there is a lesion, a “small spot of gliosis”, in the right hemisphere, in the superior colliculus area. Nobody knows what it is, and where it came from.

It is present on all MRIs I had since Feb 2010, but was noticed only this spring, even though I can clearly see it with my own eyes on all the scans. I did not even bother to look at them myself before, because I was confident that radiologists would not miss anything.

In Jan 2010 I had a stroke-like epidose after which I had numbness in the left side of the body and strange sensory attacks each time I started eating (swallowing) and each time I started reading. Furthermore, I could not read for prolonged time for the next 2 years, because of these sensations (sudden blockage of ears; heavy left hand; feeling of pressure in the head; brain getting overwhelmed with reading).

And now, nobody can tell me anything about it - because I’m in Russia, and nobody knows anything.

And recently I started having these sensations again, back in the summer of 2023, when doctors discovered that I had no diabetes, despite me being diagnosed with it in 2000 and put on insulin in 2011. I’m not joking. When I go off insulin, I have these sensations again, and then I resume insulin, they diminish.

On June 4 to June 5, at past midnight, I had an attack of numbness on the left, and for about 30 minutes it was very hard to swallow saliva. I never noticed how often I do this automatic swallowing of saliva until I had that attack. The next couple days I felt like drunk.

And nobody can tell anything about it. It’s useless going to doctors. After the ‘hard to swallow’ attack, the neurologist put me on a waiting list for an MRI scan in August, and prescribed gliatilin and a B-group multivitamin.

I lost the ability to translate for a living in November 2020, when I developed bouts of fatigue and heaviness in the left side. Now they are mostly gone, but I feel fatigued in my head. I stopped translating for money, and switched to delivering food on bicycle. I’m staying alive only because my parents provide the money for the flat maintenance bill. I’m earning just enough to buy food, keep my cat alive, and buy medications, pay for the phone and internet.

Instead of translating 10 to 20 pages of medical or pharma texts per day I can manage maybe 1 page if I try very hard. Sometimes it’s only three sentences per three hours, which really makes me despondent, so I almost stopped translating.

I postpone opening emails and private messages, sometimes for months. Sometimes I sit and force myself to open private messages on a social network, and it lasts for hours, this process of trying to concentrate my attention to open messages. I feel afraid of what these messages might contain, because I feel absolutely defenseless in this tired brain condition - I feel that if I’m somehow attacked or disparaged, I could only feel emotions but not come up with words, and that I would feel disoriented.

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I have some idea of where you are coming from. In February of last year, I suddenly got this massive headache and couldnt think. It took weeks to fully recover. At the same time I started losing weight very quickly. Then suddenly it reversed and I starting gaining weight very quickly, even more than I lost.

At the same time, my diabetes seemed to worsen.

No one has given me a sufficient explanation of what happened. This inicident is what prompted my mri, but again, they found nothing.

So, I have some idea of bizarre medical happenings with no resolution.

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My uncle, who had a diagnosis of “sluggish schizophrenia”, was given insulin coma therapy. According to him, he never felt the same after this therapy, and could hardly do anything for the rest of his life. Strangely, insulin worked a miracle for me, although not as a coma therapy, but as tiny dosages, and only for about 8 to 10 years, from 2011 to 2020.

I could work and made friends.

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