Grape-Derived Compounds May Help to Prevent Depression

Well, I’m back. Too much news lately not to share.

So this article specifically is about depression and anxiety (in mice) but it should probably be tested in sz too, because it targets synaptic plasticity and inflammation.

“Scientists have identified two grape-derived compounds that can effectively help to treat and protect against stress-induced depression in mice, and which could represent promising new candidates for treating depression in humans. The compounds, dihydrocaffeic acid (DHCA) and malvidin-3’-O-glucoside (Mal-gluc), trigger epigenetic changes in genes that affect inflammation and synaptic plasticity, mechanisms that aren’t addressed by current antidepressants.”

“Our approach to use a combination treatment of DHCA and Mal-gluc to simultaneously inhibit peripheral inflammation and modulate synaptic plasticity in the brain works synergistically to optimize resilience against chronic stress-induced depression-like phenotypes," says lead researcher Giulio Maria Pasinetti, Ph.D., Saunders Professor of Neurology at the Center for Integrative Molecular Neuroresilience, Icahn School of Medicine at Mount Sinai. “The discovery of these new, natural grape-derived polyphenol compounds targeting cellular and molecular pathways associated with inflammation may provide an effective way to treat a subset of people with depression and anxiety, a condition that affects so many people.”


The researchers found the compound was about as effective as an antidepressant at treating social avoidance in mice, and it also treated anxiety and self-neglect.

“DHCA and Mal-gluc work by modulating inflammation and synaptic plasticity, respectively. DHCA treatment was found to trigger epigenetic changes to the noncoding sequence of IL-6, which resulted in reduced production of the cytokine by T cells and macrophages. Mal-gluc was shown to modulate histone acetylation of the Rac1 gene, so that transcription activators could access the DNA and increase transcription in the brain, which influences the expression of genes responsible for synaptic plasticity.”


Too bad big pharma wont look into nutritional compounds.

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Yeah, the research $$ largely isn’t there.

Although they might go for something with just these active compounds, because they could patent that.

I think the current treatment for Parkinson’s disease is derived from a plant, so there’s that.

Would Grape Seed Extract fall under this category?

It says it’s “composed of a specific Concord grape juice, grape seed extract, and trans-reservatrol.”

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3,4-Dihydroxyhydrocinnamic acid (or Dihydrocaffeic acid, DHCA) is a
metabolite product of the hydrogenation of caffeoylquinic acids,
occurring in normal human biofluids, with potent antioxidant properties.
DHCA has been detected in human plasma following coffee ingestion (PMID
15607645 ),
and is increased with some dietary sources, such as after ingestion of
phenolic constituents of artichoke leaf extract. (PMID 15693705 )
Polyphenol-rich foods such as vegetables and fruits have been shown to
significantly improve platelet function in ex vivo studies in humans.
(PMID 16038718 )
Its antioxidant activity has been tested to reduce ferric iron in the
ferric reducing antioxidant power (FRAP) assay, and it has been
suggested that its catechol structure convey the antioxidant effect in
plasma and in erythrocytes.

TL;DR DHCA In Coffee , Artichoke leaf extract , Polyphenol - rich food Antioxidant ...reduces ferritin (always a good thing unless you are anemic)


Malvidin 3-glucoside is found in alcoholic beverages. Malvidin 3-glucoside is a pigment of skins of black grapes, also in other plants. Malvidin 3-glucoside is found in red wine


"DHCA/Mal-gluc can immediately translate into human clinical studies for
the treatment of stress disorders and depression either alone or in
combination with currently available antidepressants.”

I have coffee, artichoke leaf extract, grape seed extract, reservatrol only thing I need is red wine and I am g2g. Damn I am a teetotaler. hmm :thinking:


You can use purple grape juice. Just not too much because it has a lot of natural sugars.

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That’s because no side effects mean less pills.

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True dat!! 151413121110090807060504030201

Red wine is good antidepresant. Lol :wine_glass:


Yeah that is a problem specially if you are trying to follow a restricted carb / ketogenic diet.

There is however camu camu extract.
“Camu Camu Fruit Powder 8 oz 100% Pure Immune Booster High in Vitamin C
Myrciaria dubia, commonly known as camu camu is a small bushy riverside
tree from therainforest in Brazil and Peru, which bears a red/purple
cherry-like fruit. The extraordinarily high vitamin C content is the
most important property of the fruit. Processed powder from the fruit
pulp is now beginning to be sold in the west as a health food in powder
or capsule form. In addition to the high vitamin C content, camu camu
contains iron, riboflavin, potassium, the amino acids valine, leucine,
and serine. It is also rich in flavonoids, such as anthocyanins,
flavonols and flavanols, catechins, delphinidin 3-glucoside, cyanidin
3-glucoside, ellagic acid, and rutin; other analysis revealed the
presence of gallic and ellagic acids, suggesting that the fruit
possesses hydrolyzed tannins (gallo- and/or ellagitannins). It’s wide
range of amino acids and minerals also greatly help in the absorption of
the vitamin C.”

Anthocynanin’s generally may be useful as in wiki …

BTW - I have tried grape-seed extract + resveratrol + coffee and it rocks. Its become part of my “helps me study stack” :slight_smile:

Any other clues ?