Glycine improvement after been off almost it for a week
for negative symptoms but when i took it i felt like dying and not been able to function due to panick attacks
rapid heart rate
I think NAC might help too like Sarcosine or can this cause psychosis?
It might help for some aspects.
Does the half life matter on this med you have it in short and long half life
so i dunno what brand to take maybe try jarrow nac sustain 600 mg or bad idea?
The abstract of the study above doesn’t say what dosage was used, that’s behind a paywall…
But, I did find this other study which used 2 grams. 1 gram 2 times a day. That seems like kind of a lot. Peak levels are reached in 120 minutes, according to the paper below, but I don’t know how long it takes to be eliminated.
Interesting quote from the study linked above:
"The present study was conducted in the context of a multi-center clinical trial. Our center conducted a double-blinded and crossover study, wherein NAC was given as an add-on treatment (2 g/day for 2 months). No significant changes in the psychopathology was observed in our cohort of patients, which may be due to the relatively small sample size. Nonetheless, the effectiveness of NAC in reducing clinical severity was demonstrated over the whole set of 140 patients included in the multi-center double-blinded trial (Berk et al, 2007, unpublished work), which included data from our group of patients. An improvement on the Clinical Global Impression was observed 2 weeks after the beginning of the trial and was sustained throughout the 6-month trial period. An improvement of negative symptoms on the Positive and Negative Symptoms Scale was also significant after 6 months of treatment with NAC. These findings suggest that longer treatments and larger sample sizes may be required to observe behavioral improvements following NAC treatment, whereas the present electrophysiological effects were nonetheless reliable after a relatively short treatment duration and highlight the clinical utility of brain imaging methods. We would emphasize that although we have sufficient power to obtain statistically reliable positive results with only seven patients, confirming our results with a larger sample size will be necessary. A new and larger study of first-episode psychosis patients is currently being initiated to further investigate the results supported by the present study as well as whether an earlier intervention will be more efficient. "
To paraphrase that, this paper covers 7 people who were part of a larger study of 140 people, and over the whole 140 people there was also a measurable benefit on negative symptoms and clinical global impression. The study used NAC as an add on to treatment as usual (antipsychotics).
That stuff gave me energy but after a month made me want to go to sleep .