Geodon (Ziprasidone) and 500 calories - Scientific research

Andy · June 1, 2017, 6:10pm

ncbi.nlm.nih.gov

The impact of calories and fat content of meals on oral ziprasidone absorption: a randomized, open-label, crossover trial.

K Gandelman, JA Alderman, P Glue, I Lombardo, RR LaBadie, M Versavel and SH Preskorn, The Journal of clinical psychiatry, Jan 2009

Food is known to increase the bioavailability of ziprasidone. Therefore, we evaluated the effects of meals of differing caloric and fat content on steady-state ziprasidone exposure in a stable, treated group of subjects with DSM-IV diagnoses of schizophrenia, schizoaffective disorder, bipolar disorder, or psychotic disorder (not otherwise specified) who were already receiving oral ziprasidone as their standard therapy.Patients took ziprasidone under 6 meal conditions in randomized sequences (fasted, low calorie/low fat, low calorie/high fat, medium calorie/high fat, high calorie/low fat, and high calorie/high fat); each crossover period was separated by at least 3 days for washout of the previous meal condition. Serial blood samples were obtained over the 12 hours postdose. The study was conducted from July 27 to September 28 of 2006.Maximum ziprasidone exposures in this study were observed with high-calorie meals (1000 kcal), which were nearly twice those observed under fasting conditions. The medium-calorie meal (500 kcal) was associated with exposures similar to the high-calorie meals. Low-calorie meals (250 kcal) were associated with exposures that were approximately 60% to 90% lower than those of medium- and high-calorie meals, and approached exposures seen under fasting conditions. Fat content of the meal had no significant effect on ziprasidone absorption. The ziprasidone exposures observed with medium- and high-calorie meals had less variability than those with low-calorie meals and under fasting conditions.These results confirm that ziprasidone should be taken with food and that a meal equal to or greater than 500 kcal, irrespective of fat content, is required for optimal and reproducible bioavailability of the administered dose.

ncbi.nlm.nih.gov

Using oral ziprasidone effectively: the food effect and dose-response.

L Citrome, Advances in therapy, Aug 2009

Ziprasidone is a newer "atypical" or "second-generation" antipsychotic. Oral ziprasidone (ziprasidone hydrochloride) has been approved by the US Food and Drug Administration (FDA) for the treatment of schizophrenia, and acute manic or mixed episodes associated with bipolar disorder (with or without psychotic features). Comparisons with other second-generation antipsychotics in meta-analyses reveal similar efficacy to that observed for quetiapine or aripiprazole, but inferior efficacy to that of olanzapine or risperidone in the treatment of schizophrenia. However, the rate of dose titration and the dose achieved may have an important bearing on ziprasidone's efficacy profile, with a target dose range of 120-160 mg/day being associated with optimal symptom control and greater persistence with treatment. In addition, enhancing ziprasidone's effectiveness requires ensuring that ziprasidone is administered with a 500 kcal meal; otherwise, absorption of oral ziprasidone is substantially reduced and cannot be compensated for by increasing the prescribed dose. Regarding tolerability, ziprasidone has important advantages in that it is not associated with clinically significant weight gain or adverse changes in cholesterol, triglycerides, or glycemic control, and patients may experience moderate improvement in these measures when switching to ziprasidone from a different antipsychotic. Ziprasidone also lacks significant persistent effects on prolactin levels, is not anticholinergic, and only infrequently causes extrapyramidal side effects or postural hypotension; however, it can be associated with somnolence. Ziprasidone may prolong the electrocardiogram (ECG) QT interval but this does not appear to pose a substantial clinical problem. Provided that an adequate dose of ziprasidone is prescribed, and administered with a 500 kcal meal, ziprasidone can be effectively used to control symptoms without the long-term liabilities of metabolic side effects.

anon58900831 · June 1, 2017, 9:35pm

Ah thisis just what i had asked my doc. He said 300 is okay like latuda. Honestly i make vegan oatmeal fruit shakes which are about 4-5 00 calories max

sigarino · June 1, 2017, 9:46pm

what is vegan stuff like? , when i first started Geodon i would only eat meat and hot sauce every 12 hours when it time to take my meds no vegetables or anything,

anon58900831 · June 1, 2017, 9:52pm

I buy honey or cranberry oatmeal and use two sachets in a large cup of nutribullet
with 1 cup cashew or almond milk
1 or 2 banans
2 tablespoon Chia seeds
2 celery
half an apple
and something sweet.

It does not taste good like a decent meal but I like it plus it is easy and quick.

At night next week I will start taking 40 mg so I am planning to have a 500 calorie protein meal. Maybe lentil / rice / potatoes / some sort of protein source like tofu or soya meals etc.

I don’t like meat really. I like fish but trying to cut it off

twinklestars · June 2, 2017, 4:29am

Put some peanut butter in that shake and you’ll get to 500 calories.

It sounds pretty good actually.

Topic		Replies	Views
Geodon Absorption And Half Life Medications	5	4270	November 2, 2015
How much do you have to eat with Geodon? Medications	15	6660	October 10, 2017
Can Ziprasidone make you less hungry than usual Medications	11	601	June 16, 2022
Geodon Dosage Medications	0	787	June 25, 2017
Hi folks! I can't sleep DX'd - Sz/SzA	14	1027	June 3, 2017

Geodon (Ziprasidone) and 500 calories - Scientific research

Related topics