Schizophrenia.com

Genetic Disorder CMT offers a clue to Schizophrenia's Cause?

So I have CMT1, a disorder that affects white matter, causes diabetes, nerve fibers and axons, supposedly causes you to lose the ability to walk over time, linked to diabetes, a 50 percent chance of passing it to your children if parent has it, is progressively neurodegenerative, and I inherited it from my mother who also has psychosis.

Demyelination and damage to axons is what the genetic disorder causes. It is still unknown whether or not CMT affects the brain. But it’s a simple cause with a simple cure. Simply, being that it is caused by a problem in a gene along the chromosome along the DNA with certain mutations, and changes in these genes and proteins cause different types of CMT up to 40. 16 of these types are available in the US. PMP22 CMT1B it’s a protein disorder.

:sunny: “And I realize I am describing something that isn’t frequently “seen” by
science, and I know the scientific prejudice of needing to “see”
something for it to be real. But again I go to the analogy of the brain
cells. The dendrites are surrounded by the myelin sheath (that’s why we
eat our omega 3 fatty acids, to make sure the wiring stays separated
from eachother), and so if the wan-wu honeycomb is the myelin sheath,
and the baryonic matter is the neuron, then we baryons have to not “see”
the insulation, on principle, ‘cause if we could see it we could
penetrate it, and then we’d have a short circuit.”

Is there myelin in the brain? Because if there is it would explain my schizophrenia as a mutation that exposed my brain to toxicity. When I was younger, I got a genetic test for Charcot-Marie Tooth and was positive for the least disabling type, but have the genetic condition. It was passed over from my mom who also has psychosis and CMT. I always thought there was a link. The short-circuit, over-exercising and exhaustion caused my “break” or caused me to become exposed to neuro-toxic elements due to my poor diet and physical exertion. My brother also may have CMT, but not psychosis, but now that I know I should tell him about what I think caused it and how to prevent it from happening to him.

http://www.princeton.edu/~achaney/tmve/wiki100k/docs/Myelin.html

CMT aka Charcot Marie Toothe is a genetic disorder that is known to affect the peripheral nerves and the axon in some instances, such as mine CMT1. Cause of Charcot-Marie-Tooth Disease: CMT is caused by an inherited genetic mutation. There are rare cases in which the mutation occurs spontaneously within one egg or sperm.

Overview of Charcot-Marie-Tooth Disease

Charcot-Marie-Tooth (CMT) disease, also known as hereditary motor and sensory neuropathy (HMSN), is an inherited, degenerative nerve disorder that causes muscle weakness and atrophy in the feet, legs, hands, and forearms. CMT disease is characterized by progressive loss of use and sensation in the limbs.

http://www.healthcommunities.com/charcot-marie-tooth-disease/charcot-marie-tooth-disease-overview.shtml

Anatomy of the Nerves:

Peripheral nerves extend from
the spinal cord throughout the body. Nerve cells, or neurons, carry
impulses to and from the brain via the spinal cord. Motor neurons signal
muscles to move; sensory neurons transmit sensations, such as heat,
pain, and surface texture to the brain.
Most neurons are made up of:
a soma dendrites an axon, and synaptic terminals.

Myelin is a dielectric (electrically insulating) material that forms a layer, the myelin sheath, usually around only the axon of a neuron. It is essential for the proper functioning of the nervous system. It is an outgrowth of a type of glial cell.
The production of the myelin sheath is called myelination. In humans,
myelination begins in the 14th week of fetal development, although
little myelin exists in the brain at the time of birth. During infancy,
myelination occurs quickly, leading to a child’s fast development,
including crawling and walking in the first year. Myelination continues
through the adolescent stage of life.

T. Paus et al. (2000) report a computational analysis of structural magnetic resonance
images (see note below) obtained in 111 living children and adolescents. The authors
report the analysis reveals age-related increases in white-matter density in fiber
tracts constituting apparent corticospinal and frontotemporal pathways. The maturation
of the corticospinal tract was bilateral, but that of the frontotemporal pathway
was found predominantly in the left (speech-dominant) hemisphere. The authors
suggest these findings provide evidence for a gradual maturation, during late
childhood and adolescence, of fiber pathways presumably supporting motor and speech
functions.

The authors also suggest their finding may provide guidance for further
investigations of neurodevelopmental disorders such as schizophrenia: “the abnormal
rate of myelinization during childhood or adolescence may very well underlie the
emergence of psychotic symptomatology.” Finally, the authors suggest that the
demonstrated possibility of detecting subtle structural variations in white matter
in the living human brain opens up new avenues of research on normal and abnormal
cognitive development and in the evaluation of the long-term effects of various
treatment strategies.

What is Myelin?

Myelin
is the insulating sheath surrounding nerve cells…The myelin is the
white matter coating our nerves, enabling them to conduct impuxlses
between the brain and other parts of the body. It consists of a layer of
proteins packed between two layers of lipids.

Myelin is produced by specialized cells: oligodendrocytes in
the central nervous system, and Schwann cells in the peripheral nervous
system. Myelin sheaths wrap themselves around axons, the threadlike
extensions of neurons that make up nerve fibers.

http://myelin.org/resources/frequentlyaskedquestions.html

Each oligodendrocyte can myelinate several axons. Myelin can be destroyed
by hereditary neurodegenerative disorders such as the leukodystrophies,
and acquired by diseases such as multiple sclerosis. http://jama.jamanetwork.com/article.aspx?articleid=363048

1 Like

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