Schizophrenia.com

Wondering if there is a Link? thoughts?

CMT, also known as hereditary motor and sensory neuropathy, is one of the most common inherited neurological disorders, affecting an estimated 126,000 individuals in the United States and 2.6 million people worldwide. Nearly all cases are inherited. It is possible to have two or more types of CMT, which happens when the person has mutations in two or more genes, each of which causes a form of the disease. CMT is a heterogenous genetic disease, meaning mutations in different genes can produce similar clinical symptoms. CMT is named for the three physicians who described it in 1886. There is currently no cure for CMT but it can be managed with supportive therapy. CMT isn’t usually life-threatening and rarely affects muscles involved in vital functions like breathing. People with most forms of CMT have a normal life expectancy.

“A demyelinating disease is any condition that results in damage to the protective covering (myelin sheath) that surrounds nerve fibers in your brain, optic nerves and spinal cord. When the myelin sheath is damaged, nerve impulses slow or even stop, causing neurological problems.”

I have type 1A CMT. I have always wondered about a possible link to it causing the stress that made me diagnosed with chronic schizophrenia and others have said bipolar…often the psychiatrists are confused by how to treat it because I dont exhibit symptoms or they assume the medication is treating it…three years ago I was diagnosed with Bipolar with a good prognosis and I was taking Hydroxizine which is an anti-histamine and I was not taking Abilify or any anti-psychotics for over one year with no relapse.

CMT causes the wirings within the neurons that control synapses to deteriorate over time. Im not saying I think Charcot Marie Tooth is the direct cause of all people with schizophrenia, but that it could likely be the cause of my mom’s and mine. One link says Multiple Scerosis can be a link to neurological disorders, so Im thinking its possible that stress and issue with the brain impulses caused it in me.

This is actually giving me hope though, because thats just one cause a duplicate PMP22 Gene affecting and pronouncing stress levels…I think some of these findings are new so not from 10 years ago and people know more about treatments.

which also makes sense because if your nerves were already stressed or blocked maybe thats why it helps?

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Dad just told me at dinner that a psychologist at Johns Hopkins told him it wasn’t likely that Myelin deterioration over time caused my “schizophrenia” and that there is no myelin in the brain…but there definitely is and he only talked to that one person 10 years ago I remember it. Johns Hopkins was founded by someone who “owned” four slaves.

Cement Answers

Is there myelin in the brain? - Cement Answers

Is there myelin in the brain? In the central nervous system (CNS) — the brain and spinal cord — cells called oligodendrocytes wrap their branch-like

Psychology Today

Brain Regeneration

Myelin repair is one of the most robust ways the brain can regenerate.

Mayo Clinic

Find out more about demylinating disease like multiple sclerosis

Understanding the causes and types of demyelinating disease, like multiple sclerosis, can help guide treatment decisions and manage symptoms.

“A demyelinating disease is any condition that results in damage to the protective covering (myelin sheath) that surrounds nerve fibers in your brain, optic nerves and spinal cord. When the myelin sheath is damaged, nerve impulses slow or even stop, causing neurological problems.”

My parents have asked one psychologist from Johns Hopkins about it who shrugged off a possible link. I plan to see a neurologist and explore this further as I am unsatisifed with my current treatment. I went back the psychiatrist for an addiction and ended up being pathologized once again about the label I had previously had of schizophrenia. It hasn’t helped with the pandemic and not being able to leave the house much. Losing my car, ability to drive for work, etc.

Please don’t persist with this. I can’t varify this research tonight or spend the time on your links. You get some time to think about this approach as I’ve shut down a previous effort.

Why can’t I post this topic?

Hi. I’m going to go ahead and reply, and then relist this topic. So, basically, demyelination does cause a lot of issues. Those issues have to do with muscle coordination and pain signals. MS is a well-funded area of research, and studies have found that mood swings/depression are much more common in folks with MS. So far, it seems like there is debate over whether that is directly because of demyelination or because living with a chronic, painful, and degenerative disease is very stressful.

But the depression/mood swings in MS are treated with the same meds that we take. So, while it might be interesting to speculate on possible causes for your psych symptoms, the available treatment won’t change. This is a good question,and i hope researchers can find a definitive answer that leads to better treatment.

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I will say that, in the case of CMT,it appears that symptoms remain localized in the extremities, particularly the feet. I can’t find any research linking CMT to psychological issues, or even anything saying that psych issues are more common in people with CMT.

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This nonprofit seems to be the leading researcher in treatments for CMT. They are currently recruiting for a clinical trial. You can sign up here

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Most of this is over my head, and not just because I’m turkey-sized.

Myelin is known in layman’s terms as white matter. Gray matter = nerve cells. White matter = myelin sheath (think the insulation on electrical cords). Loss of the white matter is like an electrical cord getting stripped.

Nerves send electrical signals. When the cord is stripped, the signals end up leaking out before they reach their destination, so the message gets distorted and the area around might suffer electrical damage.

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Mmm turkey :drooling_face:

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We taste like chicken.

Burrrp.

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Charcot Marie tooth and schizophrenia

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I don’t get why ppl try to diagnose themeselves. They 're not even Drs and even Drs don’t diagnose themeselves, they have other Drs diagnose them. You are much prone to errors when diagnosing yourself.

Interesting thank you for citing those articles! @ninjastar thanks for re-opening the topic for discussion. I know that Abilify helps me and that was what I had originally been searching for online was a possible link between Apriprozole and helping with CMT type 1A. I found that anti-histamines one OTC one was mentioned are thought and have been studied to be able to help slow the degeneration of myeline and the medication is an H1 antagonist which I think is similar to anti-psychotics.

" Highlights

  • Remyelination is the regeneration of myelin—a substance that makes up about a third of the brain.
  • Scientists are honing in on drugs that promote remyelination that could be used to treat conditions like multiple sclerosis, spinal cord injury, traumatic brain injury, and stroke.
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