Conclusion: Metformin addition to olanzapine therapy showed variable effects on some metabolic parameters such as waist circumference and certain lipid parameters. However, it did show consistent effects in managing body weight/BMI, insulin resistance, triglycerides, and liver fat content. This conforms to previous but limited evidence surrounding the use of metformin in reducing metabolic adverse effects of olanzapine therapy. Based on evidence gaps, this review also proposes areas of additional research and offers recommendations, including the use of longer RCTs, larger demographics to determine if the data can be extrapolated to a wider population, and the use of varying doses to ascertain the dose-dependent effects of metformin in alleviating metabolic adverse effects associated with olanzapine therapy.
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I think k i jumped the gun switching from Zyprexa. Now that my doctor doubled my ozempic my sugar is down to 200 from 350-400.
Maybe if she bumps me up more or adds metformin my sugar will be back to normal with decent diet. Like I said im gonna continue to take zyprexa for a couple of weeks just to be sure.
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