According to a review published in Psychiatry Research , studies regarding gender-based differences to treatment with clozapine are still lacking in definitive data in some respects. Some studies have indicated that women have a lower response to treatment with clozapine, whereas others indicate the opposite; however, the evidence uniformly supports that women have a higher risk of developing diabetes, and that men are more likely to develop metabolic abnormalities and have higher cardiovascular risks from clozapine treatment.