I take 225mg clozapine at bedtime. But i still have some positive symptoms(paranoia). I’m stable on 275mg, so I just need 50mg clozapine more.
I can’t take 275mg at bedtime cuz of adverse effects like postural hypotension, bedwetting,myoclonic jerks.
So Pdoc suggested taking divided dose like 50mg in morning and 225mg at bedtime. But morning dose makes me very sleepy, I cant do anything after taking it. I’m so tired and sleepy
What should i do ? Any thoughts
I’ll probably do what the pdoc says.
I take 50 mg of Clozapine in the morning and 150 mg at night. The 50 mg in the morning doesn’t make me tired and sleep fairly well at night.
Just give it time.
Have u ever had a bed pissing problem @TheBest
Yea that goes away. I found I was more prone to that if I had a heavy blanket. Now I have a sheet and make sure I use the bathroom before I go to sleep.
@anon39015889 I wet the bed on clozapine 275mg. I wore diapers for like 1 year. I didn’t even told my pdoc about this side effect. So after 1 year i told him about it, pdoc was stunned that i wore diapers for 1 years. He fu*king immediately lowered my clozapine dose from 275mg to 200mg. That solved the bedwetting and postural hypotension problem. But eventually paranoia came back and i had to increase the dose to 225mg. But I can’t increase it further unless i take divided dose. Increasing my benzo also helped with anxiety/psychosis little bit.
I take 200mg in the morning and 300mg at night. 
Do you also pee in your bed?
Why do people piss their beds on Clozapine but not other APs like olanzapine, seroquil etc etc.
What is it about Clozapine?
Yes on occasion 
Is it because its seriously sedating ?
Yea i asked why I piss the bed, pdoc said its cuz of muscle relexant properties of meds.
Ok thanks 
I’ve taken Abilify in divided doses before.
Listen to your doctor and try taking the clozapine in divided doses.
Can’t hurt… @clinic.
My experience is that you try to be on 50 in morning.After a week you’ll get used to stay awake.I take 50(m)+(50e)+150(night).Just this week got used to take afternoon dose without sleeping.
I take 450mg at night. I also take 600mg of lithium at night and a split dose of 250mg lamotrigine. The clozapine makes me sleepy most of the time. I wouldn’t want it split. The lithium I want split.