Cariprazine - New medication that treats Negative Symptoms in Schizophrenia

This is just news from the company - so we’ll see how it does in the real world with data from third parties:

A novel antipsychotic that treats predominant persistent negative symptoms in schizophrenia and improves overall function is significantly more effective than standard antipsychotic therapy and is well tolerated, new phase 3 trial results indicate.

“What’s important is that cariprazine was significantly more effective than risperidone [Risperdal, Janssen Pharmaceuticals, Inc] at not only improving symptoms but also the functionality of patients,” George Nemeth, MD, PhD, chief medical officer, Gedeon Richter, Budapest, Hungary, told Medscape Medical News.


More info:


When do you think it will be out?

1 Like

From Wikipedia:

“The drug has a pending New Drug Application as of March 2015 for bipolar I and schizophrenia, with a decision expected by the FDA in the second quarter of 2015.”

1 Like

I want to take this drug. I wonder how long it will take to be covered by my insurance and in stock at the local pharmacy.


Is it an atypical antipsychotic?

How bad is the weight gain? I’m on Risperdal and I’m considering Geodon. Does cariprazine help with motivation?

Everything I know about the medication is in the above posting - sorry I can’t answer more questions.

Now, this is very impressive news - I am starting to show an interest in Cariprazine because of this.

1 Like

I hope it really works and becomes available soon!my main symptoms now are just negative symptoms

1 Like

Hopefully we’ll get an equivalent in the UK soon after, Olanzapine isn’t doing enough


I might try this if it doesn’t screw with my sex hormones it will be good

1 Like

There seems to be an interest in Cariprazine (Vraylar) by quite a few people on here.

Thought that I would revive this thread.

I will be trying Vraylar in a couple of days - and I do suffer from Negative symptoms.

I will be posting Updates on my experience with Vraylar.


Wave, good luck.
Let us know.

1 Like

Hope it works for you wave!

1 Like