Can someone tell me what happened with Glycine and seroquel together : S

Medications
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a few years ago i decided to add Glycine from vital nutrients to my seroquel XR i was on 150 mg XR

on normal seroquel i get tachardia above 225 mg, that last an hour.

i was on 150 mg XR and i took 1 spoon of glycine, after 30 minutes my heart started to race like hell for 4 hours, i should had called 911 i was dying my heart was in ultra overdrive…

I do not know how i survived this, this is why i am scared to try Sarcosine from profrontal i will be taking 1 mg and NAC

but i didn’t have this with 50 mg seroquel XR and glycine, just when i upped my seroquel to 150 mg XR my heart started to go in overdrive for 4 hours… this happened year ago…

I take abilify maintena 400 mg injection, the max dose, but i dont think this will affect Sarcosine and NAC from profrontal, seroquel is just dangerous on higher doses with Glycine medications

Please give me some pro advice, i am very serious, this info might help other people in distress

I am in bad shape with negative and cognitive symptoms

Sarcosine from profrontal is my only hope at this moment. I need to start treatment asap…

Is Sarcosine and NAC safe with injection of abilify and klonopin 1 mg twice daily? i will ditch the seroquel safely

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I searched and found no known interactions, maybe it’s more rare, just don’t take it together, it’s probably for the best.

Talk to your pdoc about it.

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Sarcosine and Glycine impact your body / brain in almost identical ways - they both target the NMDA receptors of the brain (sarcosine gets converted into glycine in your body, is my probably oversimplistic understanding).

So - if you had a bad reaction to Glycine, It seems to me that you would probably will get the same reaction from sarcosine. I wouldn’t take either glycine, sarcosine or D-serine (also closely related) if I had that reaction.

more info:

“Sarcosine’s main mechanism involves inhibiting a transporter, called GlyT1, which takes up glycine and D-serine into cells. This increases the levels of glycine and D-serine in the body and increases their effects.”

Source:

Generally Glycine is very well tolerated - so if you did have a bad effect its something to be careful about:

More info on Glycine:

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Is 400 mg really the max dose for Maintena? That’s what I’m on and I wonder how they determined that’s how much I need since they never started low and upped my dose. How do they determine that when you first start having psychosis? It can’t be based on weight.

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it is not glycine that is giving you the tachardia, it is the Seroquel. This is a well known side effect of it. I also get seroquel 150mg and have to take a betablocker. But i will further reduce my dosis of Seroquel in order to get rid of the tachardia.

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Ok Let me explain it to you again, : )

Seroquel gives me 1 hour tachardia when i take high dose like you
BUT when i took Glycine with it, it lasted for 4 hours before it stopped it almost killed me.

that’s the issue here, just be carefull!

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It gives me tachycardia too for a while sometimes. It’s scary like my heart is thumping out of my chest.

My doc doesn’t seem concerned. It he is very chilled and it scares me.

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it’s dangerous i took it 6 months and every night before bedtime they gave me 600 mg of normal seroquel
that pdoc abused me, don’t take seroquel high dose!

it has a QT prolongation of 12 ms seroquel, not on low doses

normal seroquel it starts at 225 mg
Seroquel XR 200 mg you can get tachardia

i used to take 150mg XR and didnt get these tachardia but i got sinus painfully near death attacks very scary

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I take 300mg immediate release seroquel morning and night. I take sarcosine and haven’t noticed any tachycardia.

Saying that when I took glycine it kinda felt like I had taken some sort of stimulant.

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yes i just think when you have tachardia from seroquel or any other med, do not combine, if you’re not sensitive to it with a med