Conclusions
These Mendelian randomization findings indicate that long-term higher plasma caffeine levels may lower the risk of bipolar disorder and MDD but increase the risk of anorexia nervosa. These results warrant further research to explore whether caffeine consumption, supplementation, or abstinence could render clinically relevant therapeutic or preventative psychiatric effects.
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I feel like my depression (I have depression, no SZ) is getting worse after caffeine. First an elevated mood, and then a crash. I hope I would be able to go off caffeine someday, or at least to minimize its consumption; when I relapse on it, I binge on it.
Maybe someday they will be able to stratify caffeine’s impact based on genes and/or subtypes of depression.
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