Any one here use memantine for negative symptoms..!

far_cry0 · November 3, 2019, 5:20pm

Its a offlevel drug… approved for alzimers…!!!

Some article suggest it might might help sz…!!

anon17132524 · November 3, 2019, 5:34pm

This article claims that memantine is safe and effective in the treatment of negative symptoms and neurocognitive performance of schizophrenia. It’s a prescription drug for Alzheimer’s. I’ve never used it.

ncbi.nlm.nih.gov

Adjunctive memantine for schizophrenia: a meta-analysis of randomized, double-blind, placebo-controlled trials.

W Zheng, XH Li, XH Yang, DB Cai, GS Ungvari, CH Ng, SB Wang, YY Wang, YP Ning and YT Xiang, Psychological medicine, Jan 2018

Dysfunction of N-methyl-D-aspartate receptor (NMDAR) is involved in the pathophysiology of schizophrenia. A meta-analysis of randomized controlled trials (RCTs) was conducted to examine the efficacy and safety of memantine, a non-competitive NMDAR antagonist, in the treatment of schizophrenia.Standardized/weighted mean differences (SMDs/WMDs), risk ratio (RR), and their 95% confidence intervals (CIs) were calculated and analyzed.Included in the meta-analysis were eight RCTs (n = 452) of 11.5 ± 2.6 weeks duration, with 229 patients on memantine (20 mg/day) and 223 patients on placebo. Adjunctive memantine outperformed placebo in the measures of Positive and Negative Syndrome Scale and Brief Psychiatric Rating Scale negative symptoms [SMD: -0.63 (95% CI -1.10 to -0.16), p = 0.009, I 2 = 77%], but not in the total, positive and general symptoms [SMD: -0.46 to -0.08 (95% CI -0.93 to 0.22), p = 0.06-0.60, I 2 = 0-74%] or the Clinical Global Impression Severity Scale [WMD: 0.04 (95% CI -0.24 to 0.32), p = 0.78]. The negative symptoms remained significant after excluding one outlying RCT [SMD: -0.41 (95% CI -0.72 to -0.11), p = 0.008, I 2 = 47%]. Compared with the placebo group, adjunctive memantine was associated with significant improvement in neurocognitive function using the Mini-Mental State Examination (MMSE) [WMD: 3.09, (95% CI 1.77-4.42), p < 0.00001, I 2 = 22%]. There was no significant difference in the discontinuation rate [RR: 1.34 (95% CI 0.76-2.37), p = 0.31, I 2 = 0%] and adverse drug reactions between the two groups.This meta-analysis showed that adjunctive memantine appears to be an efficacious and safe treatment for improving negative symptoms and neurocognitive performance in schizophrenia. Higher quality RCTs with larger samples are warranted to confirm these findings.

far_cry0 · November 3, 2019, 5:38pm

My appointment is next week…!!!

far_cry0 · November 3, 2019, 5:39pm

I will talk to my psydoc about it…!!

anon17132524 · November 3, 2019, 5:41pm

When did you start seeing a psydoc? For some reason I thought you weren’t seeing one. I hope this med helps you.

far_cry0 · November 3, 2019, 5:45pm

Nope that’s not me …!!! I am sure its wayto go another fella…

I visit doc regularly.

I will start b vitamins soon…!!

have a great day helenback…

anon17132524 · November 3, 2019, 5:46pm

You too, @far_cry0

Visit us more often if you can !!

far_cry0 · November 3, 2019, 5:56pm

Thats Cool friend …!!

Due to severe negative symptoms I might use some alternative …

I don’t know where to start from…!!!

anon17132524 · November 3, 2019, 5:58pm

Yeah, I have pace myself too.

I’m going to watch American football. Have a great day !!

far_cry0 · November 4, 2019, 2:25pm

@anon17132524 bro goodmorning …

I want to show something …

Watch it … whether it is useful or not …

Its sounds interesting…!!!

far_cry0 · November 4, 2019, 2:26pm

DelusionalSoldier · November 5, 2019, 4:39am

I hate taking alopatic medicines, but memantine helped me a lot with negatives. It was kind like a miracle.

Deux · November 5, 2019, 5:54am

I don’t have negative symptoms anymore.

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Anyone with SZ on Memantine? Medications	4	1343	May 17, 2017
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Effects of memantine added to risperidone on the symptoms of schizophrenia: A randomized double-blind, placebo-controlled clinical trial News	2	739	October 7, 2016
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Any one here use memantine for negative symptoms..!

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