Antidepressant side effects and co-occurring panic disorder

Patients who take medication for depression report more side effects if they also suffer from panic disorder, according to a new study led by researchers from the University of Illinois at Chicago published in the Journal of Clinical Psychiatry.

The researchers looked at data from 808 patients with chronic depression who were given antidepressants as part of the Research Evaluating the Value of Augmenting Medication with Psychotherapy (REVAMP) trial. Of those patients, 85 also had diagnoses of panic disorder.

Among all participants, 88 percent reported at least one side effect during the 12 week trial, which ran from 2002 through 2006. Every two weeks, antidepressant side effects were assessed, and categorized as gastrointestinal, cardiovascular, dermatological, neurological, genitourinary, sleep, or sexual functioning.

The researchers found that patients with depression and panic disorder were more likely than those with only depression to self-report gastrointestinal (47 percent vs. 32 percent), cardiovascular (26 percent vs. 14 percent), neurological (59 percent vs. 33 percent), and genital/urinary side effects (24 percent vs. 8 percent). Co-occurring panic disorder was not associated with eye or ear issues or dermatological, sleep or sexual functioning side effects compared to participants without panic disorder.

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@Sunshine did you say you had GAD or a panic disorder

I suffer from both depression and panic attack…don’t know what to take.??? any ideas …!!!

I have GAD. :slight_frown:
This article is quite interesting though.

Hey sunshine do u take anti_depressant or anti anxiety pills for GAD…!!!

I take an antidepressant (SSnRI) called Venlafaxine (Effexor) :slight_smile:

I am on 75mg effexor …but its not working right now …!!! I am feeling hard to raise myself up…!!!
i need to boost my self esteem a lot…!!!

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I’m also not feeling well at my dose either.
I’m going to ask my pdoc to raise it if possible.
Ask yours to either raise the dose or switch meds :slight_smile:

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I thought it was GAD. Just wanted to point you to this article don’t know why. Guess I could’ve phrased it better. :zipper_mouth:

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I think the concordance rate of depression and panic disorder is high (don’t know the exact percentage).

@far_cry0

You may want to ask your pdoc about taking a mood stabilizer and a benzodiazepine. Lamictal and Xanax?

Yeah we learned about this in my classes too. Apparently if you already have issues with anxiety you’re way more likely to have your anxiety made worse by ADs when starting out. The majority of people without anxiety issues who go on an AD don’t experience anxiety at all.

Zoloft didn’t give me anxiety problems but Lexapro messed me up so much I didn’t make it past two doses!!

It’s okay!
Thank you :slight_smile:
I found it informative.

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