Alteration of the gut microbiome in first-episode drug-naïve and chronic medicated schizophrenia correlate with regional brain volumes

twinklestars · February 18, 2020, 9:36pm

ncbi.nlm.nih.gov

Alteration of the gut microbiome in first-episode drug-naïve and chronic medicated schizophrenia correlate with regional brain volumes.

X Ma, H Asif, L Dai, Y He, W Zheng, D Wang, H Ren, J Tang, C Li, K Jin, Z Li and X Chen, Journal of psychiatric research, Feb 2020 08

The human gut microbiome plays an important role in the basic neurodevelopmental processes of the central nervous system and has been implicated in several neuropsychiatric disorders. However, the connection between the gut microbiome and the underlying pathogenesis of schizophrenia (SCZ) is poorly defined. Here we analyzed the faecal samples from 40 first-episode drug-naïve SCZ (FSCZ) patients, 85 chronically antipsychotic-treated SCZ (TSCZ) patients and 69 healthy controls (HCs) using 16S rRNA gene sequence to determine whether the alterations of the gut microbiome were associated with SCZ or antipsychotic treatment. In addition, we acquired the T1-weighted brain imaging data by using structural magnetic resonance imaging to test whether microbial composition correlated with structural brain signatures. Our analyses revealed low microbiome alpha-diversity indexes in TSCZ patients but not in FSCZ patients as compared to HCs. Importantly, both FSCZ and TSCZ patients had distinct changes in gut microbial composition at certain taxa including Christensenellaceae, Enterobacteriaceae, Pasteurellaceae, Turicibacteraceae at the family level and Escherichia at genus level as compared to HCs. We also found significant disturbances of gut microbial composition in TSCZ versus FSCZ patients (eg. Enterococcaceae and Lactobacillaceae). Most interestingly, our exploratory analyses found specific SCZ-associated microbiota to be correlated with the right middle frontal gyrus (rMFG) volume which was aberrant in SCZ patients. Our findings extend prior work and suggest a possible link between the gut microbiome and brain structure which may be implicated in the pathology of SCZ.

Green · February 19, 2020, 1:56pm

My digestion has always been bad. Is it the gut messing with the brain, or is it the brain messing with gut?

Wave · February 19, 2020, 2:55pm

Started taking a probiotic.
Already I’m seeing improvements.

y76 · February 19, 2020, 2:56pm

Identified risk factors are so numerous that they can fill a A4 page. Probably the addition of these risk when they reach a certain threshold made the trigger of SZ disorder.

Wave · February 19, 2020, 3:01pm

My doctor said it’s the brain messing with the gut.

Green · February 19, 2020, 3:44pm

@Wave

Yeh but no one what causes this mess.

anon90843118 · February 19, 2020, 3:45pm

I hope these aps do not mess directly with our gut biome.

I haven’t found any solid evidence on that

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Alteration of the gut microbiome in first-episode drug-naïve and chronic medicated schizophrenia correlate with regional brain volumes

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