“In a recent study published in the journal Science Advances, researchers in Sweden conducted virtual screens of over 16 million compounds using multiple receptor models developed by AlphaFold and homology modeling techniques. These models were based on different protein structures to identify trace amine-associated receptor 1 (TAAR1) agonists for the potential treatment of various neuropsychiatric conditions. They found that the AlphaFold-based screen had a higher hit rate and helped discover potent TAAR1 agonists, leading to a promising drug candidate that showed physiological effects in mice.”
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