Schizophrenia is associated with impaired cognition, which persists despite current treatments, and is an important determinant of quality of life and overall function. There is limited evidence for the efficacy of pharmacological treatments for this indication. Cognitive remediation therapy is a non-pharmacological intervention associated with improved cognitive functioning in patients who have schizophrenia, with a moderate effect size.
Physical activity can improve symptoms and social functioning in patients with schizophrenia.2 In the general population, exercise has been associated with modest improvements in cognition, but this has not been adequately explored in patients with schizophrenia. Firth and colleagues3 conducted a meta-analysis of the effects of exercise on global cognition in schizophrenia.