A recent study, published in JAMA by National Institute of Mental Health (NIMH)-funded researchers, found that the second-generation drug paliperidone palmitate was no more effective than the older drug haloperidol decanoate in treating adult patients with schizophrenia or schizoaffective disorder. However, patients on paliperidone gained weight and had increases in the reproductive hormone prolactin, while those on haloperidol did not.
When compared to haloperidol, paliperidone had no significant advantages in ratings of severity of abnormal involuntary movements, parkinsonism, or incidence of tardive dyskinesia
Our study confirms that the newer antipsychotics don’t have a lot of overall advantages over the older treatments
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