- Palmitoylethanolamide (PEA) is a dietary cannabinoid that can reduce the impact of many neuropathological mechanisms.
Anandamide is found naturally in cocoa powder and black truffles, while PEA is found in egg yolks, soybeans, and peanut oil.
I found a 2022 systematic review in Frontiers Psychiatry, of unknown quality. Citing the abstract,
preclinical evidence suggests that PEA may act as a disease-modifying-drug in the early stage of a neurocognitive disorder, while its protective effect in the frank disorder may be less relevant. Limited human research suggests that PEA supplementation reduces fatigue and cognitive impairment, the latter being also meta-analytically confirmed in 3 eligible studies. PEA improved global executive function, working memory, language deficits, daily living activities, possibly by modulating cortical oscillatory activity and GABAergic transmission.
Conflicts of interest:
Author MC has been a consultant/advisor to GW Pharma Limited, GW Pharma Italy SRL and F. Hoffmann-La Roche Limited, outside of this work.