Interesting. I thought that schizophrenia was an absolute contraindication for ADHD drugs, and this research indicates that their use “decreased the risk of hospital readmission for psychosis”. I wonder who was the comparison group (I’ve only read the abstract thus far). I noticed this abstract in the Science community on Reddit.
Abstract
Background
Although attention-deficit hyperactivity disorder (ADHD) is often comorbid with schizophrenia spectrum and other psychotic disorders (SZSPD), concerns about an increased risk of psychotic events have limited its treatment with either psychostimulants or atomoxetine.
Aims
To examine whether the risk of hospital admission for psychosis in people with SZSPD was increased during the year following the introduction of such medications compared with the year before.
Method
This was a retrospective cohort study using Quebec (Canada) administrative health registries, including all Quebec residents with a public prescription drug insurance plan and a diagnosis of psychotic disorder, defined by relevant ICD-9 or ICD-10 codes, who initiated either methylphenidate, amphetamines or atomoxetine, between January 2010 and December 2016, in combination with antipsychotic medication. The primary outcome was time to hospital admission for psychosis within 1 year of initiation. State sequence analysis was also used to visualise admission trajectories for psychosis in the year following initiation of these medications, compared with the previous year.
Results
Out of 2219 individuals, 1589 (71.6%) initiated methylphenidate, 339 (15.3%) amphetamines and 291 (13.1%) atomoxetine during the study period. After adjustment, the risk of hospital admission for psychosis was decreased during the 12 months following the introduction of these medications when used in combination with antipsychotics (adjusted HR = 0.36, 95% CI 0.24–0.54; P < 0.0001).
Conclusions
These findings suggest that, in a real-world setting, when used concurrently with antipsychotic medication, methylphenidate, amphetamines and atomoxetine may be safer than generally believed in individuals with psychotic disorders.
I don’t believe in studies anymore, only in trial and error. Lots of studies said APs help negative symptoms but they don’t, they even make them worse. Lots of studies about supplements improving negative and cognitive symptoms but in reality they don’t help, I tried them all.
I don’t trust chat GPT to be correct. It is basically using the “poll the audience” feature, except the audience is everyone who has ever posted anything online.
Since replacing the autocorrect dictionary with AI, my phone keeps trying to convince me that common misspellings of words are actually the correct spelling, just because more people get it wrong than right.
Oh yeah good point. Guess an llm would need to be trained on more specific datasets to be more accurate . Well hopefully in the future there will be better ones for that.
