“The positive symptoms of schizophrenia include hallucinations and delusions as a result of increased subcortical release of dopamine, which augments D2 receptor activation (15), and are thought to be due to a disturbed cortical pathway through the nucleus accumbens (16). The negative symptoms of schizophrenia include anhedonia, lack of motivation, and poverty of speech, which result from reduced D1 receptor activation (15) in the prefrontal cortex and decreased activity of the nucleus caudatus (16). Alterations in D (3)-receptors might also be involved in the negative symptoms of schizophrenia”
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My psychiatrist is right about that high dopamine in some brain parts/receptors causes positive symptoms and that low dopamine in other brain parts/receptors causes negative symptoms. He said thers no meds yet that target negative symptoms, at least without worsening positive symptoms. Why can’t they already cure both positive and negative symptoms at the same time?
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yea i wonder same thing…
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My dr said its pretty hard to make meds that target specific brain regions/receptors without affecting others. He said there is none yet.
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yea it makes sense… it prob isn’t easy to do… but if they can make meds that fight the positive symptoms and they know what receptor is working for negative symptoms that they would have at least already have had some med that affects it.
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I wish they got rid of both negative and positive symptoms too. It’s year 2021 and still all we get are horrible meds.
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