https://www.nature.com/articles/s41398-023-02691-0
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The page is a review article that discusses the central role of the thalamus in psychosis, lessons from neurodegenerative diseases and psychedelics. The authors propose that the thalamus is involved in generating and modulating the activity of the Default Mode Network (DMN), which is associated with altered states of consciousness, such as hallucinations, delusions, and dissociation. They suggest that ThalamoCortical Dysrhythmia (TCD) is a key mechanism that disrupts the thalamic filtering of sensory and internal information, leading to an input overload to the cortex and a loss of cortico-cortical modulations. They also compare the pathophysiology of psychosis with other conditions that involve TCD, such as Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB), which share similar presentation patterns and progression. They argue that understanding the role of the thalamus in psychosis can provide a bridge between neurology and psychiatry, and help to develop new therapeutic approaches based on psychedelic drugs or other interventions that target TCD. The article is published in Translational Psychiatry1.