https://medicalxpress.com/news/2024-05-uncovers-cell-specific-genetic-insights.amp
brain.
“We discovered which cell types express genes associated with schizophrenia risk differently, which biological functions are impacted within those cells, and which transcription factors are important for these changes,” explained lead and co-corresponding author, W. Brad Ruzicka MD, Ph.D., director of the Laboratory for Epigenomics in Human Psychopathology at McLean Hospital. “This understanding will allow future treatments to be tailored to specific genes and cell types, as well as individuals with schizophrenia.”
Through transcriptomic analysis, two distinct subpopulations of individuals with schizophrenia were identified, marked by the expression of specific excitatory and inhibitory neuronal cell states.
“Our increased mechanistic understanding of schizophrenia provides avenues for future research to unravel the genetic and environmental underpinnings of this complex disease so we can provide our patients better care.”