Sodium nitroprusside " if this drug is approved it will be an important advance in the pharmacologic treatment of schizophrenia "

After the infusion of sodium nitroprusside, a rapid (within 4 hours) improvement of symptoms was observed. The placebo and experimental groups had significant differences in the 18-item Brief Psychiatric Rating Scale total score and subscale scores, which persisted for 4 weeks after infusion.
The results clearly show a therapeutic effect of sodium nitroprusside. If this drug is approved for routine clinical use in patients with schizophrenia, this discovery will be an important advance in the pharmacologic treatment of this devastating disorder.

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It didn’t work in followup studies.

They dind’t say anything about cognitive improvements…

These findings in rats, which have an even faster metabolic rate than humans, suggest that the long-lasting effects observed in our clinical trial with SNP in humans could have been due to SNP itself

what I dislike here is that this study is from 2013.
You would have thought that if it were a breakthrough it would already go into use today.
Does it help specifically with cognition?
Thanks for posting @Shrek anything that might help us is good.


The nitric oxide donor sodium nitroprusside attenuates recognition memory deficits and social withdrawal produced by the NMDA receptor antagonist ketamine and induces anxiolytic-like behaviour in rats.

Its interesting - its already sold and used for blood pressure treatment:

Hope its not toxic!

@y76 are you willing to about your medication regime?

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