Shared molecular signature in Alzheimer's disease and schizophrenia: A systematic review of the reelin signaling pathway

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# Shared molecular signature in Alzheimer’s disease and schizophrenia: A systematic review of the reelin signaling pathway

Highlights

  • The RELN-APOER2-DAB1 pathway is key in the pathogenesis of AD and SZ.
  • In AD, pTau disrupts APOER2-DAB1 signaling, worsening neurodegeneration.
  • In SZ, Reelin signaling is altered, impacting cortical development and plasticity.
  • RELN genetics and epigenetics shape Reelin expression and progression in AD and SZ.
  • Targeting Reelin signaling may offer new therapeutic strategies for both diseases.

Back in 2006, I wrote the Reelin article in the Russian Wikipedia and basically wrote the Reelin article in the English Wikipedia, since it had been a stub before that.

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