Decomposition of brain diffusion imaging data uncovers latent schizophrenias with distinct patterns of white matter anisotropy, in NeuroImage, Vol. 120, October 2015. DOI: 10.1016/j.neuroimage.2015.06.083
“…scans of patients with schizophrenia revealed various abnormalities in portions of the corpus callosum [the structure that connects the two brain hemispheres]… patients with specific features in one part of the corpus callosum typically displayed bizarre and disorganized behavior. In other patients, irregularities in a different part of that structure were associated with disorganized thinking and speech and symptoms such as a lack of emotion. Other brain abnormalities in the corpus callosum were associated with delusions or hallucinations.”
Very interesting considering the considerable research during the late '90s and '00s suggesting that both over- and under-connection (via the corpus callosum) of specific parts of the two brain hemispheres are seen in people who are over- and under-reactive to – emotions and thoughts related to perceived threat.
This and other psychiatric issues related to the corpus callosum were described in depth in Iain McGilchrist’s The Master and his Emissary: The Divided Brain and the Making of the Western World, Cambridge, MA: Yale U. Press, 2011.
The upshot for pts with sz is that it may be possible to utilize very precise micro-surgical and/or non-invasive cross-stream radiation (like the proton guns used to destroy cancerous tumors) to knock out specific sections of the corpus callosum in sz pts.