Observation of developmental abnormalities in the brain offers clue to schizophrenia

Close examination of the hippocampus in human and mouse brains revealed that the dentate gyrus is noticeably underdeveloped in individuals with schizophrenia, providing the first clear anatomical signature for this condition. Dr. Hyman Schipper proposes that the retention of immature properties in this region of the brain into adulthood could be responsible for the disease, which doesn’t usually present in males until they are in their twenties or in females in their twenties or thirties. The findings were published in The Neuroscientist .

“Our research shows remarkable consistency between a visibly immature dentate gyrus and the emergence of schizophrenia symptoms,” Dr. Schipper points out. “This abnormality may account for many cardinal symptoms of schizophrenia because the dentate gyrus is associated with the brain’s capacity to separate and process sensory stimulation and to distinguish the real from the delusional.”



It further said the dentate gyrus was normal in sz models up until adolescence, so:

Drug therapies shown to be effective in preventing maturational arrest of the dentate gyrus in animal models could be tested in humans at-risk for schizophrenia, offering an unprecedented opportunity to possibly influence the pathogenesis of the disease and not merely its symptoms.

This sounds interesting and possibly very helpful for treatment.