Brain's Hippocampal Shape Abnormalities Predict Symptom Progression in Neuroleptic-Free Youth at Ultrahigh Risk for Psychosis

Perhaps of interest to those who think that schizophrenia is a spiritual emergency / crisis, and those people who think that the medications cause significant brain changes / harm:

Hippocampal abnormalities in the brain have been widely studied in schizophrenia spectrum populations including those at ultrahigh risk (UHR) for psychosis.

This represents the first study to use vertex analysis in a UHR sample and results suggest that abnormalities in hippocampal shape appear to reflect underlying pathogenic processes driving the progression of illness.

These findings suggest that examining shape and volume may provide an important new perspective for our conception of brain alterations in the Ultra High Risk period.