No drug treatment for negative symptoms is on the near horizon,

Health and Recovery
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https://www.health.harvard.edu/mental-health/the-negative-symptoms-of-schizophrenia

No drug treatment for negative symptoms is on the near horizon, but the search continues. One approach involves stimulation of the NMDA receptor, which regulates the release of glutamate in the prefrontal cortex. If drugs that affect negative symptoms are found, they might be tested on people with schizotypal or schizoid personality, or even on genetically vulnerable family members who may be in the early stages of schizophrenia.

One study found that cognitive therapy was most effective, surprisingly, not for delusions but for severe negative symptoms like poverty of speech.

It now looks as though schizophrenia is not one disorder but several, with genetic roots and brain malfunctions that may be entirely different or overlapping. Psychotic, negative, and cognitive symptoms could result from different underlying processes, each with a genetic basis, that occur separately or together. These processes result in biological traits or markers that are a new focus for schizophrenia research.

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Min-101 is a treatment for negative symptoms and that’s certainly on the horizon.

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It lost me at Sigma receptors.

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It took a year for me to learn NMDA. Maybe it will take another year to learn another.

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Celexa an antidepressant helps somewhat with negative symptoms

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@TheBest be more optimistic that study was from 2006 and you found that the mutations in chromosome 6 was in 2016 and then in 2018 they published an protein signaling related to this illness…

People here sometimes don’t believe, but I will tell you something that one of my teachers like to say: “A biochemist doesn’t sleep, they rest their eyelids” (he also likes to say to that in biochemistry everything is on rocks but that is for cheering up :joy:). Scientists barely sleeps, they work a lot and their paycheck is crap…

Everyone wants a cure, but there’s many things that lacks basic research, as in our illness…I believe in our lifetime we will have better treatments that will drive us to do a lot more! Be hopeful and check the dates :grin:

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